All information updated in 2017

Annual IRTG Symposium on RNA Biology



From Wednesday, Nov 15 to Thursday, Nov 16, the annual IRTG Symposium will take place in Friedrichsdorf/Taunus. Topics will cover all fields of RNA biology that are research areas within our CRC 902. The following Guest Speakers are presenting their research alongside members of our IRTG:

Nadine Schwierz-Neumann – MPI for Biophysics, Frankfurt
Niels Gehring – Universität zu Köln
Markus Wahl – Freie Universität Berlin
Renee Schröder – Max F. Perutz-Laboratories, Wien
Mario Mörl – Universität Leipzig
Jörg Hartig – Universität Konstanz
Christoph Dieterich – Uniklinikum Heidelberg
David Stanek – The Czech Academy for Sciences
Alfredo Castello – University of Oxford

Registration is now open via the following link.


Das Proteom aktiver Nervenzellen


Das Proteom aktiver Nervenzellen

Max-Planck-Forscher entwickeln eine Technik, mit der sie neue Proteine in unterschiedlichen Zelltypen des Mäusegehirns messen können

Das Gehirn besteht aus einer Vielzahl unterschiedlicher Typen von Nerven- und Gliazellen. Da sie alle das gleiche Erbgut besitzen, muss diese Vielfalt auf den von ihnen gebildeten Proteinen beruhen. Für einen bestimmten Zelltyp konnte die Gesamtheit der Proteine – das sogenannte Proteom –bislang nicht bestimmt werden. Wissenschaftler der Max-Planck-Institute für Hirnforschung und für Biophysik in Frankfurt haben nun neue Methoden entwickelt, mit denen sie Änderungen im Proteom in einem bestimmten Zelltyp erkennen können. Sie veröffentlichen diese Ergebnisse und deren Bedeutung in der Zeitschrift Nature Biotechnology.

Read more …


Publication – Fürtig, Schwalbe, Wöhnert

Evaluation of 15N-detected H-N correlation experiments on increasingly large RNAs.

Schnieders R, Richter C, Warhaut S, de Jesus V, Keyhani S, Duchardt-Ferner E, Keller H, Wöhnert J, Kuhn LT, Breeze AL, Bermel W, Schwalbe H, Fürtig B.
J. Biomol. NMR, 2017 Sep 6.

Full publication here: Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs

Abstract:  Read more …

16-21 July – Summer School in Wernigerode

Summer School 2017 Read more …

2nd RMU-RNA Salon

On Wednesday, June 28, the Goethe-Universität Frankfurt, in association with the SFB 902 and the RNA Society, will host the 2nd RNA Salon of the Rhein-Main Universitäten Associacion. Keynote Speaker will be Erin Schuman of the MPI for Brain Research, who recently received her second ERC advanced grant.

Presenting Groups:

AG Legewie (IMB Mainz) – Modelling of Biological Networks

AG Preußer (BCI, JLU Gießen) – CircRNAs & Exosomes

AG Randau (MPI Marburg) – Small RNomics & RIP-seq

AG Roignant (IMB Mainz) – RNA Modifications

AG Schmidt (IBC1, GU Frankfurt) – Ribo-seq

AG Zarnack (BMLS, GU Frankfurt) – Computational RNA Biology

Read more …

Lecture: Yun-Xing Wang

New ways to study RNA structural biology

Yun-Xing Wang

National Cancer Institute, National Institutes of Health, Maryland, USA

Friday, 2nd June 2017 – 14:00 h s.t.
Uni Campus Riedberg, Lecture Hall B2
Max-von-Laue-Str. 7 – 60438 Frankfurt

Abstract Read more …

Publication – Schwalbe, Süß, Wöhnert, Fürtig

Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation.

Steinert’ H, Sochor’ F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM, Keller H, Mooney RA, Landick R, Süß B, Fürtig B, Wöhnert J, Schwalbe H. eLife. 2017 May 25. Abstract Read more …

Publication – Schwalbe, Heilemann, Fürtig, Hengesbach

Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy.

SWarhaut S, Mertinkus KR, Höllthaler P:, Fürtig B, Heilemann M, Hengesbach M, Schwalbe H.
Nucl. Acids Res., 2017 May 19.

Full publication here: Ligand-modulated folding of the full-length adenine riboswitch probed by NMR and single-molecule FRET spectroscopy.

Abstract:  Read more …

Publication – Schwalbe, Sigurdsson

Impact of spin label rigidity on extent and accuracy of distance information from PRE data.

Schnorr KA, Gophane DB, Helmling C, Cetiner E, Pasemann K, Fürtig B, Wacker A, Qureshi NS, Gränz M, Barthelmes D, Jonker HRA, Stirnal E, Sigurdsson ST, Schwalbe H.
Nucleic Acids Research, 2017 May 12.

Full publication here: Impact of spin label rigidity on extent and accuracy of distance information from PRE data.

Abstract:  Read more …

Erin Schuman receives her second ERC Advanced Grant for NeuroRibo project

With this prestigious grant of 2.5 million Euro, Erin Schuman, Director at the Frankfurt-based Max Planck Institute for Brain Research (MPI-BR) since 2009, will study extended functions of the ribosome, the protein-making machine, in neurons. Ribosomes are complex, yet conserved, multiprotein machines and Schuman’s team will study how they are specialized to synthesize proteins in the distal aspects of neuronal dendrites.

Read more …


April 4th – Workshop on Chimera and Pymol

The workshop will be given by Milan Gerovac on Tuesday (4th of April at 4 p.m. in Room N140-210 Biocenter Riedberg).

chimera workshop grako




Publication – Tampé

Structure of the 40S–ABCE1 post-splitting complex in ribosome recycling and translation initiation.

Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.
Nature Structural & Molecular Biology, 2017 Apr 3.

Abstract   Read more …


Guest Speaker – Anna Ephrussi

Dear friends of RNA,

We are pleased to announce the first speaker of the Minerva Lecture series:

Anne Ephrussi
European Molecular Biology Laboratory (EMBL)

Assembly of mRNPs for transport within and between cells of the Drosophila germline

Wednesday, March 22, 2017

4:00 pm

Erin Schuman
MPI for Brain Research
Synaptic Plasticity

Michaela Müller-McNicoll
Cluster of Excellence Macromolecular Complexes (CEF)
Goethe Universität Frankfurt

Lecture hall, MPI for Brain Research
Max-von-Laue-Str. 4, 60438 Frankfurt

Lecture: Benedikt Beckmann

Novel methods to study RNA-protein interactions

Monday, March 20th 2017; 2 pm TU Darmstadt, B261/102

For further information see: Beckmann Lab

Lecture: Volker Busskamp

Paul Ehrlich and Ludwig Darmstaedter Nachwuchspreis 2017
Joint Seminar – MPI-BP, MPI-BR, CEF, SFB 902, SFB 807
Dr. Volker Busskamp
Technical University Dresden
Center for Regenerative Therapies Dresden
“Regenerating neuronal function, cellular compartments and cell types”
Wednesday, 15th March 2017  – 17:00 s.t. Uhr
Max Planck Institute of Biophysics, Lecture Hall 0.10
Max-von-Laue-Str. 3 – 60438 Frankfurt
Campus Riedberg 
Guests are welcome!
For the organzation of a visiting schedule, I kindly ask you to send an email to email hidden; JavaScript is required as soon as possible if you are interested in meeting with Volker Busskamp on March 15th.


Publication – Heckel, Schuman

Activity-dependent spatially localized miRNA maturation in neuronal dendrites

Sambandan S, Akbalik G, Kochen L, Rinne J, Kahlstatt J, Glock C, Tushev G, Alvarez-Castelao B, Heckel A, Schuman EM
Science. 2017 Feb 10. Abstract   Read more …

Publication – Schwalbe, Fürtig, Hengesbach

NMR structural profiling of transcriptional intermediates reveals riboswitch regulation by metastable RNA conformations.

Helmling CWacker AWolfinger MTHofacker ILHengesbach MFürtig BSchwalbe H.
J. Am. Chem. Soc., 2017 Jan 30.

Full publication here: NMR structural profiling of transcriptional intermediates reveals riboswitch regulation by metastable RNA conformations.

Abstract:  Read more …

Publication – Schwalbe, Süß

Ligand binding to 2΄-deoxyguanosine sensing riboswitch in metabolic context

Kim YB, Wacker A, von Laer K, Rogov VV, Suess B, Schwalbe H.
Nucleic Acids Res, 2017 Jan 23. Abstract   Read more …

Lecture: Kai Papenfort

Prof. Dr. Kai Papenfort (Ludwig-Maximilians-Universität München)


Title:     From Strings of Nucleotides to Collective Behavior: “Lessons from Vibrio cholerae”

Homepage LMU


Tuesday, January 17th, 2017, 5.15 pm

Campus Riedberg, Biozentrum, Raum NU 260/3.13


Quorum-sensing (QS), is a process of bacterial cell-to-cell communication that relies on
the production, release, and population-wide detection of extracellular signal molecules.
Processes controlled by QS are unproductive when undertaken by an individual bacterium but
become effective when undertaken by the group. QS controls many important microbial
processes including bioluminescence, secretion of virulence factors, competence and biofilm
formation. In this study, we identified and characterized of a novel bacterial communication
system present in Vibrio cholerae. This system consists of a transcriptional regulator, VqmA
and a small regulatory RNA (sRNA), VqmR. VqmR is activated by VqmA and functions as a
trans-acting regulator through base-pairing with multiple target mRNAs. Among these targets
are key factors for biofilm formation and virulence factor expression in V. cholerae indicating
that VqmA/R could participate in the regulation of complex behaviors. Indeed, our results
show that VqmA binds to and is activated by an extracellular signal, which we determined as
the novel autoinducer molecule, DPO. DPO is a new molecule to biology and is produced by
diverse pro- and eukaryotes. Further, we obtained evidence that the signaling molecule is
produced by commensal species of the host microbiota and that VqmA/R plays an important
role during V. cholerae pathogenesis and the communication with other bacteria.

Publication – Prisner, Sigurdsson

Noncovalent and site-directed spin labeling of duplex RNA

Kamble NR, Gränz M, Prisner TF, Sigurdssond ST.
Chem. Commun., 2016 Nov 30. Abstract   Read more …


Publication – Wöhnert

A Stably Protonated Adenine Nucleotide with a Highly Shifted pKa Value Stabilizes the Tertiary Structure of a GTP-Binding RNA Aptamer

Wolter AC, Weickhmann AK, Nasiri, AH, Hantke K, Ohlenschläger O, Wunderlich CH, Kreutz C, Duchardt-Ferner E, Wöhnert J.
Angewandte Chemie Int. Ed., 2017 Jan 2. Abstract   Read more …