All information updated in 2019

Guest Speaker – Boris Görke

On Thursday, 12.12.2019, 5.15 pm

 

Boris Görke (Max-Perutz-Labs, Wien), will give an SFB 902 lecture:

„A regulatory network controlling bacterial cell envelope synthesis at the post-transcriptional level“.

Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!
Abstract:
Gram-negative bacteria such as E. coli possess a cell envelope consisting of peptidoglycan and an outer membrane, which provides protection against environmental stresses. Synthesis of glucosamine-6-phosphate (GlcN6P) by enzyme GlmS represents the first and rate-limiting step in the cell envelope synthesis pathway. In order to ensure continuous cell envelope synthesis, GlcN6P homeostasis is required, which is achieved through a post-transcriptional regulatory circuit composed of small RNAs (sRNAs) GlmY and GlmZ and the RNA-binding protein RapZ. GlmZ activates glmS translation by base-pairing. When GlcN6P is ample, GlmZ is bound by adaptor protein RapZ and inactivated by cleavage through recruitment of RNase E. Decreasing GlcN6P concentrations provoke accumulation of the homologous sRNA GlmY, which acts as decoy and sequesters RapZ thereby counteracting GlmZ decay. The crystal structure of RapZ revealed a novel type of RNA-binding protein, which putatively evolved from re-purpose of a glycolytic enzyme. The active form of RapZ corresponds to a tetramer, which may activate the likewise tetrameric RNase E in an encounter complex to cleave sRNA GlmZ that is presumably sandwiched between the two tetramers. Notably, RapZ also represents the sought GlcN6P sensor: RapZ binds GlcN6P with high affinity and rapZ mutants are blind for this metabolite. Upon GlcN6P depletion, RapZ stimulates a transcription factor through interaction to increase GlmY expression levels. Thus, RapZ has a moonlighting function and controls production of its own decoy GlmY, which subsequently sequesters the available RapZ protein into long-lived ribonucleoprotein complexes, thereby counteracting GlmZ decay.

Guest Speaker – Chase Beisel

On Thursday, 21.11.2019, 5.15 pm

 

Chase Beisel (Helmholtz Zentrum für Infektionsforschung, Würzburg), will give an SFB 902 lecture:

„From CRISPR biology to versatile technologies“.

Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!

Guest Speaker – Marina Chekulaeva

On Tuesday, 05.11.2019, 5.15 pm

 

Marina Chekulaeva (Max-Delbrück-Zentrum, Berlin), will give an SFB 902 lecture:

„Mechanisms of RNA localization in neurons“.

Venue: Campus Riedberg, Lecture hall N260/3.13

Guests are welcome!
Abstract:
The proper subcellular localization of RNAs and proteins is crucial for their function. It is particularly important for highly polarized cells, such as oocytes, migrating andgrowing cells, neurons. In mRNAs, they are mediated by specific cis-regulatory elements, so called zip-codes. These elements are bound by trans-acting factors (RBPs, miRNAs), which regulate transport, stability or translation. So far, our knowledge is restricted to only a few examples of zip-codes and regulatory factors. We aim to identify these elements genome-wide and dissect molecular mechanisms underlying their function. To identify proteins and RNAs that are differentially localized and translated between neuronal subcellular compartments – neurites and soma – we developed a neurite/soma separation scheme in combination with mass spectrometry, RNA-seq, 3′-mRNAseq, Ribo-seq and bioinformatic analyses. Our results demonstrate that mRNA localization is the primary mechanism for protein localization in neurites and may account for more than a half of the neurite-localized proteome. Moreover, we identified multiple neurite-targeted non-coding RNAs and RBPs with potential regulatory roles. Using a combination of PAR-CLIP, RIP, and CRISPR/Cas-mediated knockouts, we are dissecting the roles of selected neurite-targeted RBPs and miRNAs in establishment of neuronal polarity. Relying on the same neurite/soma separation scheme, we are mapping cis-regulatory elements mediating RNA localization and investigating architecture of local proteome, transcriptome and translatome in motor neuron disorders.

Publication – Heilemann, Schuman

Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography.

C. Böger, A.-S. Hafner, T. Schlichthärle, M. T. Strauss, S. Malkusch,U. Endesfelder, R. Jungmann, E. M. Schuman, M. Heilemann.
Solid State NMR

Full publication here: Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography

Abstract:  Read more …

Summer School on Nucleic Acid Chemistry and Synthetic Biology

28th July – 2nd of August 2019, Würzburg, Germany:

The faculty of Chemistry and Pharmacy at the University of Würzburg (Germany) will organize an International Summer School on Nucleic Acid Chemistry and Synthetic Biology from 28th July – 2nd of August 2019 (http://go.uni-wuerzburg.de/summerschool).

The scientific program offers lectures and workshops on various topics in the field of nucleic acids research, with a focus on functional nucleic acids and synthetic as well as natural DNA and RNA modifications. The school is aimed at advanced Master’s as well as Ph.D. students or postdocs. You and your research group may be interested in the topics presented, so I wanted to inform you about the Summer School (see attached Poster).

We would be delighted to welcome your students to Würzburg. Students will also have the chance to present their research projects on posters, and some abstracts will be selected for short talks. The summer school is free of charge (excluding accommodation) and enrolled participants can earn a certificate for active participation in the summer school.

If you have any questions or need further information please feel free to contact us:

Summer School on Nucleic Acid Chemistry and Synthetic Biology
Faculty of Chemistry and Pharmacy
University of Wuerzburg
Am Hubland, D-97074 Wuerzburg
Fon: +49(0)931 31 81813
Fax: +49(0)931 31 84607
Mail: email hidden; JavaScript is required
Internet: go.uni-wuerzburg.de/summerschool

SummerSchool_2019_Nucleic_Acid_Chemistry

Aptamers in Bordeaux – June 28-29 2019 – International Conference

Conference Homepage

IRTG Summer School

The last Summer School of the SFB 902’s 2nd funding period will take place in Bayreuth from June 24th to June 28th.
We are looking forward to 4 days of scientific program, guest speaker Claus Dieter Kuhn and an exceptional free time adventure!
35 places available, first come first serve – register now!

Registration

Hausprospekt

Publication – Corzilius, Suess

Dynamic nuclear polarization on a hybridized hammerhead ribozyme: An explorative study of RNA folding and direct DNP with a paramagnetic metal ion cofactor.

D. Daube,  M. Vogel,   B. Suess,  B. Corzilius.
Solid State NMR

Full publication here: Dynamic nuclear polarization on a hybridized hammerhead ribozyme: An explorative study of RNA folding and direct DNP with a paramagnetic metal ion cofactor

Abstract:  Read more …

6th RNA Salon

The 6th RNA Salon will take place on April 8th, 2019 — 12:30 pm 

Venue: FIAS Campus Riedberg — Room 0.100

6. RMU-RNA Salon – Flyer(1)

Program:

Presenting groups:

Reinier Boon (ICR, GU Frankfurt) – lncRNAs & aging

Sven Danckwardt (CTH, JGU Mainz) – alternative polyadenylation

Christoph Dieterich (DZHK, Heidelberg) – computational RNA biology

Martin Hengesbach (IOCCB, GU Frankfurt) – dynamics of RNA modifications

Meike Saul (Biology, TU Darmstadt) – extracellular RNAs

Jennifer Winter (IHG, JGU Mainz) – miRNAs & neurobiology

We have also 4 Short talks from selected abstracts! The best talk will win a price sponsored by GeneXPro!

Please register until thursday, 4.4.2019 for free at http://bit.do/RMU-RNA-Salon6!

We cordially invite you to stay for diner and meet with the speakers.

Contact:

Michaela Müller-McNicoll (Ph.D.)

Juniorprofessor “RNA Regulation in Higher Eukaryotes”

Cluster of Excellence Macromolecular Complexes (CEF)
Goethe University Frankfurt
Institute for Cell Biology and Neuroscience
Max-von-Laue-Str. 13
60438 Frankfurt am Main

Tel: 069 798 42079
http://www.bio.uni-frankfurt.de/52678296/Group

SYNPEP – ERC Grant for Helge Bode

Press release Goethe University

Tags:

GRADE-Trainingsprogramm für das Sommersemester 2019 online

Sehr geehrte Damen und Herren,

liebe Programmkoordinatorinnen, liebe Programmkoordinatoren,

hiermit möchte ich Sie darüber informieren, dass das neue GRADE-Trainingsprogramm für das Sommersemester 2019 nun online ist.

Auch diesmal enthält das Programm eine Reihe bewährter Workshops sowie neue Themen, die wir in diesem Semester anbieten möchten. Zudem finden Sie in unserer Übersicht alle universitätsweite Angebote für Promovierende und Postdocs.

Alle Informationen zum aktuellen Angebot finden Sie auf unserer Website unter dem Link: http://tinygu.de/f766.

Die Broschüre zum GRADE-Trainingsprogramm kann online über folgenden Link abgerufen werden: http://www.uni-frankfurt.de/76660797/Brosch%C3%BCre_SoSe19_Online.pdf

Publication – Corzilius, Suess

Complex formation of the tetracycline‐binding aptamer investigated by specific cross‐relaxation under DNP.

V. Aladin,  M. Vogel,  R. Binder,  I. Burghardt,  B. Suess,  B. Corzilius.
Angewandte Chemie Int. Ed. 2019

Full publication here: Complex formation of the tetracycline‐binding aptamer investigated by specific cross‐relaxation under DNP

Abstract:  Read more …

RNA Club

Dear friends of RNA,

Save the date. The next RNA Club will take place on February, 27th at 5 pm.

Room: N260 / 313

The program will be announced very soon (www.rnaclub.de).

We hope to see you there and discuss over beer and Pizza.

Michaela & Beatrix

Guest Speaker – Janosch Hennig

On Thursday, 07.02.2019, 4.00 pm

 

Janosch Hennig (EMBL, Heidelberg), will give an SFB 902 lecture:

„Structural insights into MLE-Unr-roX2 complex assembly during early
steps of Drosophila dosage compensation“
.Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!

Guest Speaker – Amanda E. Hargrove

On Thursday, 17.01.2018, 4.15 pm

 
Prof. Amanda E. Hargrove, Duke University Medical School Durham, North Carolina, USA, will give an SFB 902 lecture

„Deciphering patterns in selective small molecule: RNA interactions“.

Venue: Goethe University, Campus Riedberg, Lecture Hall N100/B3

Guests are welcome!