Guest Speaker – Julien Bethuné

On Thursday, 30.01.2020, 5.15 pm


Julien Bethuné (Heidelberg University Biochemistry Center), will give an SFB 902 lecture:

„Analysis of context-dependent protein complexes with next-generation
proximity proteomics assays“

Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!
Since its initial description in 2012, the proximity-dependent biotinylation technique BioID has
established itself as a reliable alternative to the classical Affinity Purification-MS approach for the
identification of protein-protein interactions. Recently we engineering split-BioID, a proteinfragments
complementation assay that greatly enhances the resolution of BioID by allowing the
analysis of context-dependent protein complexes. Applied to the miRNA silencing pathway, split-
BioID let us identify the 4EHP-binding protein GIGYF2 as a novel miRISC-associated factor. The 4EHPGIGYF2
dimer has been proposed to be recruited by RNA-binding proteins to stimulate the
repression of translation of their associated transcripts. In line with this model we found that the
miRISC component TNRC6 directly binds to GIGYF2 which in turns promotes miRNA-mediated
translation repression. More recently we uncovered an additional mechanism of GIGYF2-mediated
repression that is independent of 4EHP but rather relies on the CCR4-NOT deadenylation complex.
This suggests that GIGYF2 is part of two distinct functional units that exert distinct modes of
repression on their associated target mRNAs. To define the composition of these context-dependent
GIGYF2 complexes, we have developed more versatile proximity labeling assays that rely on a smaller
labeling enzyme with improved labeling kinetics and that can be used in a split assay format.

Guest Speaker – Neva Caliskan

On Tuesday, 28.01.2020, 5.15 pm


Neva Caliskan (Helmholtz-Institut für RNA-basierte Infektionsforschung, Würzburg), will give an SFB 902 lecture:

„Single-Molecule and Ensemble Analysis of Protein-mediated Frameshifting“.

Venue: Campus Riedberg, lecture hall: N260/3.13

Guests are welcome!
Three bases encoding for an amino acid seem to represent the universal feature of the genetic code, yet ribosomes have evolved to read the code in different ways by altering the triplet periodicity of the reading frame. This phenomenon is called programmed ribosome frameshifting (PRF). PRF requires specific cis-acting elements – a slippery site followed by a stable RNA structure. PRF efficiency is also affected by trans-acting factors, including proteins, miRNAs and metabolites. While the general mechanisms of PRF and the involvement of cis-acting elements in this process are well understood, the regulation of these events is still vastly understudied. Additionally, the interactions of these factors with the RNA and the translation machinery have not yet been completely understood. Recent advances in single-molecule techniques allow to study these events at the molecular level and thus unveil hitherto unrecognised details. In this study, we chose the encephalomyocarditis virus (EMCV) 2A protein as a model to study PRF regulation. The expression of this protein is essential for frameshifting on the EMCV mRNA, and inhibition of PRF leads to severely reduced virulence. We investigated the interplay of the 2A protein with its frameshifting-RNA target. To do so, we combined single-molecule techniques, such as optical tweezers and confocal microscopy, together with HPLC-MS and microscale thermophoresis (MST). We anticipate these assays to be a starting point in analysing the translational kinetics of frameshifting and its interplay by RNA binding factors. Furthermore, recent examples of identification of such factors indicate that they play a major role in PRF regulation and understanding their mode of action will certainly uncover new fundamental principles of RNA-based gene regulation.

Guest Speaker – Boris Görke

On Thursday, 12.12.2019, 5.15 pm


Boris Görke (Max-Perutz-Labs, Wien), will give an SFB 902 lecture:

„A regulatory network controlling bacterial cell envelope synthesis at the post-transcriptional level“.

Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!
Gram-negative bacteria such as E. coli possess a cell envelope consisting of peptidoglycan and an outer membrane, which provides protection against environmental stresses. Synthesis of glucosamine-6-phosphate (GlcN6P) by enzyme GlmS represents the first and rate-limiting step in the cell envelope synthesis pathway. In order to ensure continuous cell envelope synthesis, GlcN6P homeostasis is required, which is achieved through a post-transcriptional regulatory circuit composed of small RNAs (sRNAs) GlmY and GlmZ and the RNA-binding protein RapZ. GlmZ activates glmS translation by base-pairing. When GlcN6P is ample, GlmZ is bound by adaptor protein RapZ and inactivated by cleavage through recruitment of RNase E. Decreasing GlcN6P concentrations provoke accumulation of the homologous sRNA GlmY, which acts as decoy and sequesters RapZ thereby counteracting GlmZ decay. The crystal structure of RapZ revealed a novel type of RNA-binding protein, which putatively evolved from re-purpose of a glycolytic enzyme. The active form of RapZ corresponds to a tetramer, which may activate the likewise tetrameric RNase E in an encounter complex to cleave sRNA GlmZ that is presumably sandwiched between the two tetramers. Notably, RapZ also represents the sought GlcN6P sensor: RapZ binds GlcN6P with high affinity and rapZ mutants are blind for this metabolite. Upon GlcN6P depletion, RapZ stimulates a transcription factor through interaction to increase GlmY expression levels. Thus, RapZ has a moonlighting function and controls production of its own decoy GlmY, which subsequently sequesters the available RapZ protein into long-lived ribonucleoprotein complexes, thereby counteracting GlmZ decay.

RNA Club — Wednesday — 11.12.2019 — 5 pm — Biozentrum — Room N100 0.15

Dear friends of RNA,

Our next RNA Club will take place on December, 11th at 5 pm.

We have an exciting program that you can find in the attached flyer
and under the usual links:

www.rnaclub.de or www.sfb902.de

We hope to see you there and discuss over Glühwein and Pizza.

Michaela & Beatrix


Program: RNACLUB_20191211


Michaela Müller-McNicoll (Ph.D.)

Juniorprofessor “RNA Regulation in Higher Eukaryotes”

Cluster of Excellence Macromolecular Complexes (CEF)
Goethe University Frankfurt
Institute for Cell Biology and Neuroscience
Max-von-Laue-Str. 13
60438 Frankfurt am Main

Tel: 069 798 42079

Guest Speaker – Chase Beisel

On Thursday, 21.11.2019, 5.15 pm


Chase Beisel (Helmholtz Zentrum für Infektionsforschung, Würzburg), will give an SFB 902 lecture:

„From CRISPR biology to versatile technologies“.

Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!

Guest Speaker – Marina Chekulaeva

On Tuesday, 05.11.2019, 5.15 pm


Marina Chekulaeva (Max-Delbrück-Zentrum, Berlin), will give an SFB 902 lecture:

„Mechanisms of RNA localization in neurons“.

Venue: Campus Riedberg, Lecture hall N260/3.13

Guests are welcome!
The proper subcellular localization of RNAs and proteins is crucial for their function. It is particularly important for highly polarized cells, such as oocytes, migrating andgrowing cells, neurons. In mRNAs, they are mediated by specific cis-regulatory elements, so called zip-codes. These elements are bound by trans-acting factors (RBPs, miRNAs), which regulate transport, stability or translation. So far, our knowledge is restricted to only a few examples of zip-codes and regulatory factors. We aim to identify these elements genome-wide and dissect molecular mechanisms underlying their function. To identify proteins and RNAs that are differentially localized and translated between neuronal subcellular compartments – neurites and soma – we developed a neurite/soma separation scheme in combination with mass spectrometry, RNA-seq, 3′-mRNAseq, Ribo-seq and bioinformatic analyses. Our results demonstrate that mRNA localization is the primary mechanism for protein localization in neurites and may account for more than a half of the neurite-localized proteome. Moreover, we identified multiple neurite-targeted non-coding RNAs and RBPs with potential regulatory roles. Using a combination of PAR-CLIP, RIP, and CRISPR/Cas-mediated knockouts, we are dissecting the roles of selected neurite-targeted RBPs and miRNAs in establishment of neuronal polarity. Relying on the same neurite/soma separation scheme, we are mapping cis-regulatory elements mediating RNA localization and investigating architecture of local proteome, transcriptome and translatome in motor neuron disorders.

Summer School on Nucleic Acid Chemistry and Synthetic Biology

28th July – 2nd of August 2019, Würzburg, Germany:

The faculty of Chemistry and Pharmacy at the University of Würzburg (Germany) will organize an International Summer School on Nucleic Acid Chemistry and Synthetic Biology from 28th July – 2nd of August 2019 (http://go.uni-wuerzburg.de/summerschool).

The scientific program offers lectures and workshops on various topics in the field of nucleic acids research, with a focus on functional nucleic acids and synthetic as well as natural DNA and RNA modifications. The school is aimed at advanced Master’s as well as Ph.D. students or postdocs. You and your research group may be interested in the topics presented, so I wanted to inform you about the Summer School (see attached Poster).

We would be delighted to welcome your students to Würzburg. Students will also have the chance to present their research projects on posters, and some abstracts will be selected for short talks. The summer school is free of charge (excluding accommodation) and enrolled participants can earn a certificate for active participation in the summer school.

If you have any questions or need further information please feel free to contact us:

Summer School on Nucleic Acid Chemistry and Synthetic Biology
Faculty of Chemistry and Pharmacy
University of Wuerzburg
Am Hubland, D-97074 Wuerzburg
Fon: +49(0)931 31 81813
Fax: +49(0)931 31 84607
Mail: email hidden; JavaScript is required
Internet: go.uni-wuerzburg.de/summerschool


IRTG Summer School

The last Summer School of the SFB 902’s 2nd funding period will take place in Bayreuth from June 24th to June 28th.
We are looking forward to 4 days of scientific program, guest speaker Claus Dieter Kuhn and an exceptional free time adventure!
35 places available, first come first serve – register now!



6th RNA Salon

The 6th RNA Salon will take place on April 8th, 2019 — 12:30 pm 

Venue: FIAS Campus Riedberg — Room 0.100

6. RMU-RNA Salon – Flyer(1)


Presenting groups:

Reinier Boon (ICR, GU Frankfurt) – lncRNAs & aging

Sven Danckwardt (CTH, JGU Mainz) – alternative polyadenylation

Christoph Dieterich (DZHK, Heidelberg) – computational RNA biology

Martin Hengesbach (IOCCB, GU Frankfurt) – dynamics of RNA modifications

Meike Saul (Biology, TU Darmstadt) – extracellular RNAs

Jennifer Winter (IHG, JGU Mainz) – miRNAs & neurobiology

We have also 4 Short talks from selected abstracts! The best talk will win a price sponsored by GeneXPro!

Please register until thursday, 4.4.2019 for free at http://bit.do/RMU-RNA-Salon6!

We cordially invite you to stay for diner and meet with the speakers.


Michaela Müller-McNicoll (Ph.D.)

Juniorprofessor “RNA Regulation in Higher Eukaryotes”

Cluster of Excellence Macromolecular Complexes (CEF)
Goethe University Frankfurt
Institute for Cell Biology and Neuroscience
Max-von-Laue-Str. 13
60438 Frankfurt am Main

Tel: 069 798 42079

RNA Club

Dear friends of RNA,

Save the date. The next RNA Club will take place on February, 27th at 5 pm.

Room: N260 / 313

The program will be announced very soon (www.rnaclub.de).

We hope to see you there and discuss over beer and Pizza.

Michaela & Beatrix

Guest Speaker – Janosch Hennig

On Thursday, 07.02.2019, 4.00 pm


Janosch Hennig (EMBL, Heidelberg), will give an SFB 902 lecture:

„Structural insights into MLE-Unr-roX2 complex assembly during early
steps of Drosophila dosage compensation“
.Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!

Guest Speaker – Amanda E. Hargrove

On Thursday, 17.01.2018, 4.15 pm

Prof. Amanda E. Hargrove, Duke University Medical School Durham, North Carolina, USA, will give an SFB 902 lecture

„Deciphering patterns in selective small molecule: RNA interactions“.

Venue: Goethe University, Campus Riedberg, Lecture Hall N100/B3

Guests are welcome!

Guest Speaker – Andrea Sinz

On Tuesday, 27.11.2018, 4.15 pm

Prof. Dr. Andrea Sinz, Martin-Luther University Halle-Wittenberg, will give an SFB 902 lecture

Cross-Linking/Mass Spectrometry for Investigating Protein Complexes: Where Are We Now and Where Should We Go From Here?“.Venue: Goethe University, Campus Riedberg, seminar room N100/1.14

Guests are welcome!

Guest Speaker – Krzysztof Sobczak

On Thursday, 15.11.2018, 5.15 pm

Prof. Dr. Krzysztof Sobczak, Adam Mickiewicz University, Poznań / Poland, will give an SFB 902 lecture

Transcriptome changes caused by toxic RNA in myotonic dystrophy“.Venue: TU Darmstadt, Campus Botanischer Garten, lecture hall: B101/52

Guests are welcome!


Dear friends of RNA,

we are happy to announce the 5. RMU-RNA Salon event “Genomics approaches in RNA Biology”.

5. RMU-RNA Salon – Flyer

The RMU-RNA Salon is designed as a series of mini-symposia to bring together scientists interested in RNA biology within the Rhine-Main area to increase the awareness for available methods and to fuel the interactions:

When: Wednesday, October 24th 2018, 12:30 am – 6:30 pm

Where: Biomedizinisches Forschungszentrum (BMFZ) Marburg


Katja Strässer (IBC, JLU Gießen) – mRNA packaging & export

Presenting groups:

Arnold Grünweller (IPC, PU Marburg) – RNA viruses

Aline Koch (IPP, JLU Gießen) – RNAi in plants

Julien Bethune (BZH, Uni Heidelberg) – RBPs & endomembranes

Andreas Krueger (IMM, GU Frankfurt) – miRNAs & T-cell development

Marcel Schulz (ICR, GU Frankfurt) – Systems Biology

Jennifer Winter (IHG, JGU Mainz) – miRNAs & neuronal development

Please register for free at http://bit.do/RMU-RNA-Salon5 !

We cordially invite you to present your own research and meet with the speakers.

Abstracts for short talks and posters are welcome!

Guest Speaker – Boris Eliseev

Next week – on Friday, 7th September 201812:30 h s.t.

Dr. Boris Eliseev, EMBL, Grenoble / France, will give a lecture
in a joint SFB 902 & SFB 807 seminar:

„Structure of a human cap-dependent 48S translation pre-initiation complex“.
Venue: Biocenter N100, Lecture Hall B3 / Campus Riedberg
Guests are welcome!

Guest Speaker – Lukas Sušac

On Friday, 31st August 201812:30 h s.t.

Dr. Lukas Sušac, University of California, Los Angeles / USA, will give a lecture
in a joint CEF, SFB 902 & SFB 807 seminar:

„Structure of Telomerase with Telomeric DNA“.
Venue: Biocenter / Campus Riedberg, seminar room 015 / N100
Guests are welcome!

Understanding RNA-based Regulation in Cells -Registration NOW open!!

SFB 902 Symposium – 29.+30.08.2018

Otto-Stern-Zentrum, Campus Riedberg


more Info Read more …

Practical Course: From Ensembles to Single-Molecule Analysis – Modern Methods of RNP Analysis, 8-12 October 2018, Regensburg

The biology of ribonucleoprotein particles (RNPs) is an important and quickly expanding area of current life science research. Especially for young and less experienced researchers in this field it is often difficult to keep an overview over and to identify and select the optimal combination of analytical tools required to solve their various questions.

Therefore, the Graduate Research Academy RNA Biology organizes a practical course for PhD students with the aim to introduce the participants to a selection of innovative new approaches and state-of-the-art methodology in RNP biology research. Participants will receive hands-on training by renowned experts in the field and have the possibility to discuss their own research projects with invited speakers and local experts to further their own research projects.

In addition to the scientific excellence of the invited speakers the practical course builds on a strong local methodological expertise since all of the presented techniques are actively used by at least one research team within the Collaborative Research Center SFB960 (www.sfb960.de).

The practical course “From Ensembles to Single-Molecule Analysis – Modern Methods of RNP Analysis” will take place from 8 to 12 October 2018 in Regensburg. Course attendance is free. Registration deadline is 15 July 2018.

For further information and for registration please visit following website: https://www.rnabiology-regensburg.de/index.php?browse=150


4. Mini-Symposium “Molecular mechanisms of posttranscriptional regulation” on methods to study processing, structure, and translation of mRNAs as well as non-coding RNAs in disease-related contexts.

Keynote Speaker:

  • Stefanie Dimmeler (ICR, GU Frankfurt) – non-coding RNAs

Guest speaker:

  • Veronika Herzog (IMBA, Vienna) – metabolic RNA-seq

more information available on the Homepage of the IMB, Mainz

Rolf Sammet Guestprofessorship 2018: Eric Westhof

RNA – Chemistry and Architecture
May 21—25 | 2018


more info: Sammet Homepage of the Goethe University


Guest Speaker – Konrad Förstner

Konrad Förstner, Head of the Core Unit Systems Medicine
Julius-Maximilians-Universität Würzburg will give a talk titled:

Translating high-throughput sequencing data into biological insights

Thursday, 03th May 2018
17.15 pm

Technische Universität Darmstadt

Campus Botanischer Garten, N101/lecture hall 52

PI workshop 3rd funding period

On April 16th 6 17th, all PIs of the SFB 902 are presenting and discussing their ideas and projects for the 3rd SFB 902 funding period.

April, 16th: 11 am, Biozentrum Campus Riedberg, N100/0.15

April 17th: 11 am, Biozentrum Campus Riedberg, N100/B3

Guest Speaker – Kwaku Dayie

Kwaku Dayie
University of Maryland

What is the big deal about ‘invisible’ RNA conformational states in Biology?

Thursday, 29th March 2018
4.00 pm

Goethe-University Frankfurt

Campus Riedberg, N100/lecture hall B2

Guest Speaker – Dr. Sabine Brantl

Dr. Sabine Brantl
AG Bakteriengenetik, Universität Jena

Small RNAs and small peptides

Tuesday, 27th March 2018
3.00 pm

Goethe-University Frankfurt

Campus Riedberg, N100/lecture hall B2

Conference – 5th Meeting of Regulating with RNA in Bacteria & Archaea

The 5th Meeting of Regulating with RNA in Bacteria & Archaea
will take place in
March 19-22, 2018 • Seville/Spain
more information here

IRTG Winter School

This year’s Winter School will take place in Altglashütten, Schwarzwald, from March 4th to 8th.

Exciting talks, fun in the snow and  intensive interactions will hopefully lead to an enjoyable event and, eventually, to successful PhD projects

Please register here

EMBO course – iCLIP: Genomic views of protein-RNA interactions

Dear friends of RNA,

we are happy to announce the third edition of our EMBO course “iCLIP: Genomic views of protein-RNA interactions’, which will take place at the CRG in Barcelona from June 3rd to June 9th, 2018.

The course is targeted to Junior researchers (mainly PhDs and Postdocs) who are interested in Protein/RNA interactions.

We would be grateful  if you could forward this email to interested colleagues.

Registration deadline is March 1st 2018.

You can find more info about the course here

RNA Club

Dear friends of RNA,

The next RNA Club will take place on February, 28th at 5 pm.

Room and program will be announced soon (www.rnaclub.de).

We hope to see you there and discuss over beer and Pizza.

Michaela & Beatrix

contact for more info:
Michaela Müller-McNicoll (Ph.D.)

Guest Speaker – Dr. Zasha Weinberg

Dr. Zasha Weinberg
Department of Computer Science, Leipzig University

Computational discovery of novel classes of bacterial non-coding RNAs

Thursday, 8th February 2018
12.30 pm
TU Darmstadt, lecture hall: B261/102

Abstract: The discovery of new classes of non-coding RNAs (ncRNAs) can reveal information about the biological processes that involve these ncRNAs as well as yielding general insights into RNA biochemistry and gene regulation. Riboswitch RNAs directly sense a metabolite and regulate genes accordingly. We devised a strategy to find riboswitches that have evolved specificity to a new metabolite ligand. Such specificity changes are well known in proteins, but only a few examples are known in RNA. I will also describe a more general search strategy for novel structured ncRNAs on a multi-genome/metagenome scale. This search revealed 224 novel ncRNAs of various types. I will also show computational predictions that have been experimentally confirmed.


Gender Equality – Postdoc-Fokus-Programm für unabhängige Forschungsanträge

The office for Gender Consulting of the Goethe University announces a program for Early-Career-Researchers. It covers third-party funding applications up to 6 years after earning the doctorate, child-care off-times are considered.

Deadline is January 19th, 2018.

Find more info here:



Annual IRTG Symposium on RNA Biology



From Wednesday, Nov 15 to Thursday, Nov 16, the annual IRTG Symposium will take place in Friedrichsdorf/Taunus. Topics will cover all fields of RNA biology that are research areas within our CRC 902. The following Guest Speakers are presenting their research alongside members of our IRTG:

Nadine Schwierz-Neumann – MPI for Biophysics, Frankfurt
Niels Gehring – Universität zu Köln
Markus Wahl – Freie Universität Berlin
Renee Schröder – Max F. Perutz-Laboratories, Wien
Mario Mörl – Universität Leipzig
Jörg Hartig – Universität Konstanz
Christoph Dieterich – Uniklinikum Heidelberg
David Stanek – The Czech Academy for Sciences
Alfredo Castello – University of Oxford

Registration is now open via the following link.


16-21 July – Summer School in Wernigerode

Summer School 2017 Read more …

2nd RMU-RNA Salon

On Wednesday, June 28, the Goethe-Universität Frankfurt, in association with the SFB 902 and the RNA Society, will host the 2nd RNA Salon of the Rhein-Main Universitäten Associacion. Keynote Speaker will be Erin Schuman of the MPI for Brain Research, who recently received her second ERC advanced grant.

Presenting Groups:

AG Legewie (IMB Mainz) – Modelling of Biological Networks

AG Preußer (BCI, JLU Gießen) – CircRNAs & Exosomes

AG Randau (MPI Marburg) – Small RNomics & RIP-seq

AG Roignant (IMB Mainz) – RNA Modifications

AG Schmidt (IBC1, GU Frankfurt) – Ribo-seq

AG Zarnack (BMLS, GU Frankfurt) – Computational RNA Biology

Read more …

Lecture: Yun-Xing Wang

New ways to study RNA structural biology

Yun-Xing Wang

National Cancer Institute, National Institutes of Health, Maryland, USA

Friday, 2nd June 2017 – 14:00 h s.t.
Uni Campus Riedberg, Lecture Hall B2
Max-von-Laue-Str. 7 – 60438 Frankfurt

Abstract Read more …

Erin Schuman receives her second ERC Advanced Grant for NeuroRibo project

With this prestigious grant of 2.5 million Euro, Erin Schuman, Director at the Frankfurt-based Max Planck Institute for Brain Research (MPI-BR) since 2009, will study extended functions of the ribosome, the protein-making machine, in neurons. Ribosomes are complex, yet conserved, multiprotein machines and Schuman’s team will study how they are specialized to synthesize proteins in the distal aspects of neuronal dendrites.

Read more …


April 4th – Workshop on Chimera and Pymol

The workshop will be given by Milan Gerovac on Tuesday (4th of April at 4 p.m. in Room N140-210 Biocenter Riedberg).

chimera workshop grako




Guest Speaker – Anna Ephrussi

Dear friends of RNA,

We are pleased to announce the first speaker of the Minerva Lecture series:

Anne Ephrussi
European Molecular Biology Laboratory (EMBL)

Assembly of mRNPs for transport within and between cells of the Drosophila germline

Wednesday, March 22, 2017

4:00 pm

Erin Schuman
MPI for Brain Research
Synaptic Plasticity

Michaela Müller-McNicoll
Cluster of Excellence Macromolecular Complexes (CEF)
Goethe Universität Frankfurt

Lecture hall, MPI for Brain Research
Max-von-Laue-Str. 4, 60438 Frankfurt

Lecture: Benedikt Beckmann

Novel methods to study RNA-protein interactions

Monday, March 20th 2017; 2 pm TU Darmstadt, B261/102

For further information see: Beckmann Lab

Lecture: Volker Busskamp

Paul Ehrlich and Ludwig Darmstaedter Nachwuchspreis 2017
Joint Seminar – MPI-BP, MPI-BR, CEF, SFB 902, SFB 807
Dr. Volker Busskamp
Technical University Dresden
Center for Regenerative Therapies Dresden
“Regenerating neuronal function, cellular compartments and cell types”
Wednesday, 15th March 2017  – 17:00 s.t. Uhr
Max Planck Institute of Biophysics, Lecture Hall 0.10
Max-von-Laue-Str. 3 – 60438 Frankfurt
Campus Riedberg 
Guests are welcome!
For the organzation of a visiting schedule, I kindly ask you to send an email to email hidden; JavaScript is required as soon as possible if you are interested in meeting with Volker Busskamp on March 15th.


Lecture: Kai Papenfort

Prof. Dr. Kai Papenfort (Ludwig-Maximilians-Universität München)


Title:     From Strings of Nucleotides to Collective Behavior: “Lessons from Vibrio cholerae”

Homepage LMU


Tuesday, January 17th, 2017, 5.15 pm

Campus Riedberg, Biozentrum, Raum NU 260/3.13


Quorum-sensing (QS), is a process of bacterial cell-to-cell communication that relies on
the production, release, and population-wide detection of extracellular signal molecules.
Processes controlled by QS are unproductive when undertaken by an individual bacterium but
become effective when undertaken by the group. QS controls many important microbial
processes including bioluminescence, secretion of virulence factors, competence and biofilm
formation. In this study, we identified and characterized of a novel bacterial communication
system present in Vibrio cholerae. This system consists of a transcriptional regulator, VqmA
and a small regulatory RNA (sRNA), VqmR. VqmR is activated by VqmA and functions as a
trans-acting regulator through base-pairing with multiple target mRNAs. Among these targets
are key factors for biofilm formation and virulence factor expression in V. cholerae indicating
that VqmA/R could participate in the regulation of complex behaviors. Indeed, our results
show that VqmA binds to and is activated by an extracellular signal, which we determined as
the novel autoinducer molecule, DPO. DPO is a new molecule to biology and is produced by
diverse pro- and eukaryotes. Further, we obtained evidence that the signaling molecule is
produced by commensal species of the host microbiota and that VqmA/R plays an important
role during V. cholerae pathogenesis and the communication with other bacteria.

Lecture: Rolf Backofen

Prof. Rolf Backofen (Universität Freiburg)


Title:     How to make Sense out of CLIP-seq data

Homepage Uni Freiburg


Wednesday, December 14th, 2016, 5.15 pm

TU Darmstadt, B101/52 (‟kleiner Hörsaal“)


It is becoming increasingly clear that a RNA-binding proteins are key elements in regulating the cell’s transcriptome. Thus, unraveling the interaction network of the RNA-binding proteins by determining their binding sites is becoming an increasingly important topic. There are several high-throughput methods available to detect binding sites such as CLIP-seq. Since not all possible binding sites are covered due to differential expression in tissues and developmental states, the main problem is to come up with good motif descriptions to find missing binding sites and to evaluate the binding strength. Our new approach GraphProt uses an advanced machine learning approach based on our graph-kernel, and is able to use both structural profiles as well as detailed 2D-structures, and predicts missing binding sites with a high accuracy. We will discuss several applications, showing that the use of binding models is even superior to using the peaks from a CLIP experiment in analysing RBP-based regulation.

SFB Conference: RNA Structural Biology

The SFB 902 presents: RNA Structural Biology



Dmitri Svergun
Modesto Orozco
Karl Bertram
Cameron Mackereth
Konstantinos Stellos
Michael Sattler
Martin Hengesbach
David Lilley
Daniel Wilson
Elke Durchard-Ferner
Mark Helm


Forschungskolleg Humanwissenschaften
Am Wingertsberg 4
61348 Bad Homburg vor der Höhe, Germany

28 & 29 November 2016

Poster RNA Structural Biology

Program here

Abstract Book here: abstract-book-online

RNA Club

16th November 2016

RNA-Club – Special Edition
Goethe Universität Frankfurt
Campus Riedberg
N260/3.13, 5:00 pm

RNA Club

TRAM SFB 807 & mpibp: Invitation to the Malvern Workshop on 15/11/16

The Malvern Instruments GmbH workshop is hosted by TRAM SFB807 and mpibp.

TIME: 15 November 2016

REGISTRATION: via http://doodle.com/poll/u2gsa7z9gv4uh6yf

Goethe University Frankfurt, Biocenter N210 / 3.03 (Talks)
Max-Planck-Institut für Biophysik (Test Measurings)

Contact: Katharina Dolata (email hidden; JavaScript is required)

SFB 902 -IRTG Welcome BBQ

BBQ welcoming new members of the IRTG

On the 20th of October the IRTG will organize a BBQ for all PhDs and PostDocs (associated and full members). The BBQ will welcome all new IRTG members which joined during the year. Furthermore, the event will be used as a general information event spreading and discussing recent and upcoming IRTG-related events.

See you there!


Joint International Meeting: Perspectives in Vascular Biology

The Joint International Meeting: Perspectives in Vascular Biology is organized by the Gesellschaft für Mikrozirkulation und Vaskuläre Biologie and the SFB 834 – Endothelial Signalling and Vascular Repair

Goethe University Hospital Frankfurt
Lecture theatre 23-3
Theodor-Stern Kai 7
60590 Frankfurt, Germany

26–28 September 2016



Felix Bloch Lectureship for Björn Corzilius!

Congratulations to Björn Corzilius, who was selected for this year´s Felix-Bloch-Lecturer at the FGMR meeting in September by the GDCh.Björn Corzilius

More Info:

FGMR 2016 Homepage

GDCh News


4-9 Sept – Summer School Kleinwalsertal

Summer School 2016 Read more …

21 Jul – Talk by Frederic Pontvianne

Dr. Frederic Pontvianne from the Saez Vasquez Group, Université de Perpignan, talks about “Identification of nucleolus-associated chromatin domains reveals the role of the nucleolus in the 3D organisation of the A. thaliana genome”.

Thursday, 21/07/16 at 17:00 st
Campus Riedberg, N260/R. 3.13