General

Guest Speaker – Julien Bethuné

On Thursday, 30.01.2020, 5.15 pm   Julien Bethuné (Heidelberg University Biochemistry Center), will give an SFB 902 lecture: „Analysis of…

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Guest Speaker – Neva Caliskan

On Tuesday, 28.01.2020, 5.15 pm   Neva Caliskan (Helmholtz-Institut für RNA-basierte Infektionsforschung, Würzburg), will give an SFB 902…

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Guest Speaker – Boris Görke

On Thursday, 12.12.2019, 5.15 pm   Boris Görke (Max-Perutz-Labs, Wien), will give an SFB 902 lecture: „A regulatory network controlling…

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RNA Club — Wednesday — 11.12.2019 — 5 pm — Biozentrum — Room N100 0.15

Dear friends of RNA, Our next RNA Club will take place on December, 11th at 5 pm. We have an exciting program that you can find in the…

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The major goal of Collaborative Research Centre 902 (CRC, Sonderforschungs- bereich 902) is to unravel the relationship between the structural versatility and conformational dynamics of RNA and its biological functions on a fundamental level. Such investigations will allow us to understand RNA-based regulatory processes in biological systems and to design new RNA modules that can exert novel functions, ultimately also in cells. The CRC is devoted to the analysis of the dynamics and function of RNA-ligand complexes ranging from smaller synthetic or natural riboswitches to large ribonucleoproteins including the ribosome, the RNA-silencing machinery and the editosome.

Part A is devoted to the development and optimization of new methods for the investigation of RNA properties and function. These novel tools will be applied to understand the role of specific structural elements and conformational dynamics to induce regulatory functions of RNA, from model systems to riboswitch RNA. The developed tools will also be applied to systems defined in Part B, encompassing important RNA-protein complexes (RNP).

Part B investigates the multiple roles of RNA as regulatory constituent in important RNP complexes, with special emphasis on the core and auxiliary translational machineries. Regulatory function encompasses architectural, guiding and modifying functions, and also functions in non-conventional translation initiation and translation reprogramming.