A9: Gerhard Hummer

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Abteilung Theoretische Biophysik
Max-Planck-Institut für Biophysik
Max-von-Laue-Str. 3
60438 Frankfurt am Main, Germany
Phone +49 (69) 6303 2500
Homepage Hummer Department


Personal data
Date/Place of birth 12/02/1966 in Feldkirch, Austria


1985-1990 Mag.rer.nat. (Physik) Universität Wien
1990-1992 Dr.rer.nat. (Physik) Universität Wien & Max-Planck-Institut für Biophysikalische Chemie, Göttingen („sub auspiciis praesidentis“)
1993-1996 Postdoctoral Fellow, Los Alamos National Laboratory, Los Alamos, NM, USA

Research Experience

1996-1999 Technical Staff Member (PI) and Team Leader, Los Alamos Natl. Lab
1999-2002 Investigator, Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, MD, USA
2002-2013 Senior Investigator, Laboratory of Chemical Physics, NIDDK, National Inst. Health; Chief Theoretical Biophysics Section (2006-13), Deputy Lab Chief Lab. (2012-13)
2013- Director, Max Planck Institute of Biophysics, Department of Theoretical Biophysics, Frankfurt/M

Honors and Awards

1993 Promotio sub auspiciis praesidentis, Vienna, Austria
2005 Elected Fellow of the American Physical Society
2010 Raymond and Beverly Sackler International Prize in Biophysics
2010 Nancy Nossal Scientific Mentorship Award, National Institutes of Health
2015 Pitzer Lecturer, University of California Berkeley

Ten most relevant publications (2009-2014)

Best RB & Hummer G (2009) Optimized molecular dynamics force fields applied to the helix-coil transition of polypeptides. J. Phys. Chem. B 113: 9004–15. Available at http://dx.doi.org/10.1021/jp901540t.
Johnson ME & Hummer G (2011) Nonspecific binding limits the number of proteins in a cell and shapes their interaction networks. Proc. Natl. Acad. Sci. USA 108, 603-608. Available at http://dx.doi.org/10.1073/pnas.1010954108.
Rosta E, Nowotny M, Yang W & Hummer G (2011) Catalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations. J. Am. Chem. Soc. 133: 8934–41. Available at http://dx.doi.org/10.1021/ja200173a.
Boura E, Rózycki B, Herrick DZ, Chung HS, Vecer J, Eaton WA, Cafiso DS, Hummer G & Hurley JH (2011) Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Proc. Natl. Acad. Sci. U. S. A. 108: 9437–42. Available at http://dx.doi.org/10.1073/pnas.1101763108.
Cossio P & Hummer G (2013) Bayesian analysis of individual electron microscopy images: Towards structures of dynamic and heterogeneous biomolecular assemblies. J. Struct. Biol. 184, 427-437. Available at http://dx.doi.org/10.1016/j.jsb.2013.10.006.
Okazaki K & Hummer G (2013) Phosphate release coupled to rotary motion of F1-ATPase. Proc. Natl. Acad. Sci. U. S. A. 110: 16468–73. Available at http://dx.doi.org/10.1073/pnas.1305497110.
Best RB, Hummer G & Eaton WA (2013) Native contacts determine protein folding mechanisms in atomistic simulations. Proc. Natl. Acad. Sci. U. S. A. 110: 17874–9. Available at http://dx.doi.org/10.1073/pnas.1311599110.
Kaila VRI, Schotte F, Cho H.-S., Hummer G & Anfinrud PA (2014) Reconciling contradictions in time-resolved x-ray structures of early intermediates in the photocycle of photoactive yellow protein. Nature Chemistry 6, 258-259. Available at http://dx.doi.org/10.1038/nchem.1898.
Rosta E, Yang W & Hummer G (2014) Calcium inhibition of ribonuclease H1 two-metal ion catalysis. J. Am. Chem. Soc. 136, 3137-3144. Available at http://dx.doi.org/10.1021/ja411408x.
Kaila VRI, Wikström M & Hummer G (2014) Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I. Proc. Natl. Acad. Sci. U. S. A. 111: 6988–93. Available at http://dx.doi.org/10.1073/pnas.1319156111.