B17: Jens Wöhnert

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Institut für Molekulare Biowissenschaften
RNA-Strukturbiologie
N200 / Raum Nr. 2.04
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 9
60438 Frankfurt am Main, Germany
Phone +49 (0)69 798-29523
Homepage AK Wöhnert

Personal data

Date/Place of birth 10/07/1970 in Schwedt/O.

Education

1991-1996 Diploma (Biochemistry), Martin-Luther-University Halle, Germany
1996-2001 Ph.D. (Structural Biology), Institute of Molecular Biotechnology and Friedrich Schiller-University Jena, Germany
2000-2002 Postdoctoral Fellow with Prof. Schwalbe, Massachussetts Institute of Technology
2002-2003 Postdoctoral Fellow with Prof. Schwalbe, Goethe University Frankfurt, Germany

Research Experience

2003-2006 Independent Junior Research Group Leader, SFB 579 “RNA-ligand interactions”, Johann-Wolfgang-Goethe University Frankfurt
2006-2008 Assistant Professor, Department of Biochemistry, University of Texas Health Science Center San Antonio, USA
2008 Aventis Foundation Professorship (W2) for Chemical Biology, Department of Biological Sciences, Goethe University Frankfurt

Honors and Awards

2001 Postdoctoral Fellowship DAAD
2000 R.R. Ernst Price of the GDCh
1997-1998 Kekulé-Fellowship of the Fonds der Chemischen Industrie

Ten most relevant publications (2009-2014)

 
Wurm JP, Meyer B, Bahr U, Held M, Frolow O, Kötter P, Engels JW, Heckel A, Karas M, Entian K-D & Wöhnert J (2010) The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. Nucleic Acids Res. 38: 2387–98. Available at http://dx.doi.org/10.1093/nar/gkp1189.
 
Duchardt-Ferner E, Weigand JE, Ohlenschläger O, Schmidtke SR, Suess B & Wöhnert J (2010) Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch. Angew. Chem. Int. Ed. 49: 6216–9. Available at http://dx.doi.org/10.1002/anie.201001339.
 
Duchardt-Ferner E, Ferner J & Wöhnert J (2011) Rapid identification of noncanonical RNA structure elements by direct detection of OH···O=P, NH···O=P, and NH2···O=P hydrogen bonds in solution NMR spectroscopy. Angew. Chem. Int. Ed. 50: 7927–30. Available at http://dx.doi.org/10.1002/anie.201101743.
 
Veith T, Martin R, Wurm JP, Weis BL, Duchardt-Ferner E, Safferthal C, Hennig R, Mirus O, Bohnsack MT, Wöhnert J & Schleiff E (2012) Structural and functional analysis of the archaeal endonuclease Nob1. Nucleic Acids Res. 40: 3259–74. Available at http://dx.doi.org/10.1093/nar/gkr1186.
 
Wurm JP, Griese M, Bahr U, Held M, Heckel A, Karas M, Soppa J & Wöhnert J (2012) Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs. RNA 18: 412–20. Available at http://dx.doi.org/10.1261/rna.028498.111.
 
Wacker A, Buck J, Richter C, Schwalbe H & Wöhnert J (2012) Mechanisms for differentiation between cognate and near-cognate ligands by purine riboswitches. RNA Biol. 9: 672–80. Available at http://dx.doi.org/10.4161/rna.20106.
 
Christ NA, Bochmann S, Gottstein D, Duchardt-Ferner E, Hellmich UA, Düsterhus S, Kötter P, Güntert P, Entian K-D & Wöhnert J (2012) The first structure of a lantibiotic immunity protein, SpaI from Bacillus subtilis, reveals a novel fold. J. Biol. Chem. 287: 35286–98. Available at http://dx.doi.org/10.1074/jbc.M112.401620.
 
Steimer L, Wurm JP, Linden MH, Rudolph MG, Wöhnert J & Klostermeier D (2013) Recognition of two distinct elements in the RNA substrate by the RNA-binding domain of the T. thermophilus DEAD box helicase Hera. Nucleic Acids Res. 41: 6259–72. Available at http://dx.doi.org/10.1093/nar/gkt323.
 
Hellmich UA, Weis BL, Lioutikov A, Wurm JP, Kaiser M, Christ NA, Hantke K, Kötter P, Entian K-D, Schleiff E & Wöhnert J (2013) Essential ribosome assembly factor Fap7 regulates a hierarchy of RNA-protein interactions during small ribosomal subunit biogenesis. Proc. Natl. Acad. Sci. U. S. A. 110: 15253–8. Available at http://dx.doi.org/10.1073/pnas.1306389110.
 
Gottstein-Schmidtke SR, Duchardt-Ferner E, Groher F, Weigand JE, Gottstein D, Suess B & Wöhnert J (2014) Building a stable RNA U-turn with a protonated cytidine. RNA 20: 1163-72. Available at http://dx.doi.org/10.1261/rna.043083.