B12: Martin Hengesbach

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Institut für Organische Chemie und Chemische Biologie
N160 / 3.OG / Raum Nr. 316
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 7
60438 Frankfurt am Main, Germany
Phone +49 (0)69 798-29931
Homepage Hengesbach Group

Martin Hengesbach

Personal data
Date/Place of birth 11/07/1980 in Heidelberg


2001-2004 Bachelor of Science (Molecular Biotechnology), University Heidelberg
2004-2007 Master of Science (Molecular Biotechnology), University Heidelberg

Research Experience

2007-2009 Dr. rer. nat (summa cum laude) Biology with Prof. Dr. Mark Helm, University Heidelberg (now Mainz)
2010-2012 Postdoctoral Fellow with Prof. Michael D. Stone, UCSC, USA
2013 Independent work as Junior Group Leader, Goethe University Frankfurt/M.

Honors and Awards

2014 Adjunct Investigator, Cluster of Excellence “Macromolecular Complexes”
2010-2012 DFG Research scholarship
2010 MLP Dissertation prize, University of Heidelberg
2008-2009 PhD Scholarship Landesgraduiertenförderung Baden-Württemberg

Most relevant publications (2009-2014)

Hengesbach M & Schwalbe H (2014) Structural basis for regulation of ribosomal RNA 2’-o-methylation. Angew. Chem. Int. Ed. 53: 1742–4. Available at http://dx.doi.org/10.1002/anie.201309604.
Hengesbach M, Kim N-K, Feigon J & Stone MD (2012) Single-molecule FRET reveals the folding dynamics of the human telomerase RNA pseudoknot domain. Angew. Chem. Int. Ed. 51: 5876–9. Available at http://dx.doi.org/10.1002/anie.201200526.
Kobitski AY, Hengesbach M, Seidu-Larry S, Dammertz K, Chow CS, van Aerschot A, Nienhaus GU & Helm M (2011) Single-molecule FRET reveals a cooperative effect of two methyl group modifications in the folding of human mitochondrial tRNA(Lys). Chem. Biol. 18: 928–36. Available at http://dx.doi.org/10.1016/j.chembiol.2011.03.016.
Hengesbach M, Akiyama BM & Stone MD (2011) Single-molecule analysis of telomerase structure and function. Curr. Opin. Chem. Biol. 15: 845–52. Available at http://dx.doi.org/10.1016/j.cbpa.2011.10.008.
Dammertz K, Hengesbach M, Helm M, Nienhaus GU & Kobitski AY (2011) Single-molecule FRET studies of counterion effects on the free energy landscape of human mitochondrial lysine tRNA. Biochemistry 50: 3107–15. Available at http://dx.doi.org/10.1021/bi101804t.
Hengesbach M, Voigts-Hoffmann F, Hofmann B & Helm M (2010) Formation of a stalled early intermediate of pseudouridine synthesis monitored by real-time FRET. RNA 16: 610–20. Available at http://dx.doi.org/10.1261/rna.1832510.