B13: Katharina Zarnack

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Buchmann Institut für Molekulare Lebenswissenschaften
Raum Nr. 3.655
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 15
60438 Frankfurt am Main, Germany
Phone +49 (0)69 798-42506
Homepage Zarnack Group

Kathi Zarnack

Personal data
Date/Place of birth 12/26/1976 in Munich


1996-2002 Diploma in Biology, Ludwig-Maximilians University, Munich
2003-2007 Ph.D. (Molecular Biology and Genetics) with Prof. Dr. R. Kahmann, Philipps University Marburg at the Max-Planck Institute for Terrestrial Microbiology, Marburg
2007-2008 Postdoctoral fellow with PD Dr. M. Feldbrügge at the Max-Planck Institute for Terrestrial Microbiology, Marburg
2009-2013 Postdoctoral fellow with Prof. Dr. N. Luscombe at the EMBL European Bioinformatics Institute (EBI), Hinxton, Cambridge, UK
2013-2014 Staff Scientist with Prof. Dr. N. Luscombe at the CRUK London Research Institute, London, UK

Research Experience

2014- Junior Group Leader at the Buchmann Institute for Molecular Life Sciences, Frankfurt/Main

Honors and Awards

2010 Marie Curie Actions Cofund EMBL Interdisciplinary Postdoc (EIPOD) fellowship. In collaboration with Prof. Dr. M. Hentze at the EMBL in Heidelberg, Germany
2003 PhD fellowship awarded by the International Max Planck Research School (IMPRS), Marburg, Germany

Most relevant publications (2009-2014)

Zarnack K*, König J*, Tajnik M, Martincorena I, Eustermann S, Stévant I, Reyes A, Anders S, Luscombe NM & Ule J (2013) Direct competition between hnRNP C and U2AF65 protects the transcriptome from the exonization of Alu elements. Cell 152: 453–66. Available at http://dx.doi.org/10.1016/j.cell.2012.12.023 *equal contribution .
König J, Zarnack K, Luscombe NM & Ule J (2011) Protein-RNA interactions: new genomic technologies and perspectives. Nat. Rev. Genet. 13: 77–83. Available at http://dx.doi.org/10.1038/nrg3141.
Koepke J, Kaffarnik F, Haag C, Zarnack K, Luscombe NM, König J, Ule J, Kellner R, Begerow D & Feldbrügge M (2011) The RNA-binding protein Rrm4 is essential for efficient secretion of endochitinase Cts1. Mol. Cell. Proteomics 10: M111.011213. Available at http://dx.doi.org/10.1074/mcp.M111.011213.
Tollervey JR, Wang Z, Hortobágyi T, Witten JT, Zarnack K, Kayikci M, Clark TA, Schweitzer AC, Rot G, Curk T, Zupan B, Rogelj B, Shaw CE & Ule J (2011) Analysis of alternative splicing associated with aging and neurodegeneration in the human brain. Genome Res. 21: 1572–82. Available at http://dx.doi.org/10.1101/gr.122226.111.
König J, Zarnack K, Rot G, Curk T, Kayikci M, Zupan B, Turner DJ, Luscombe NM & Ule J (2011) iCLIP–transcriptome-wide mapping of protein-RNA interactions with individual nucleotide resolution. J. Vis. Exp. Available at http://dx.doi.org/10.3791/2638.
Wang Z, Kayikci M, Briese M, Zarnack K, Luscombe NM, Rot G, Zupan B, Curk T & Ule J (2010) iCLIP predicts the dual splicing effects of TIA-RNA interactions. PLoS Biol. 8: e1000530. Available at http://dx.doi.org/10.1371/journal.pbio.1000530.
König J*, Zarnack K*, Rot G, Curk T, Kayikci M, Zupan B, Turner DJ, Luscombe NM & Ule J (2010) iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution. Nat. Struct. Mol. Biol. 17: 909–15. Available at http://dx.doi.org/10.1038/nsmb.1838 *equal contribution .
Zarnack K & Feldbrügge M (2010) Microtubule-dependent mRNA transport in fungi. Eukaryot. Cell 9: 982–90. Available at http://dx.doi.org/10.1128/EC.00030-10.
Vollmeister E, Haag C, Zarnack K, Baumann S, König J, Mannhaupt G & Feldbrügge M (2009) Tandem KH domains of Khd4 recognize AUACCC and are essential for regulation of morphology as well as pathogenicity in Ustilago maydis. RNA 15: 2206–18. Available at http://dx.doi.org/10.1261/rna.1817609.
König J, Baumann S, Koepke J, Pohlmann T, Zarnack K & Feldbrügge M (2009) The fungal RNA-binding protein Rrm4 mediates long-distance transport of ubi1 and rho3 mRNAs. EMBO J. 28: 1855–66. Available at http://dx.doi.org/10.1038/emboj.2009.145.