B14: Julia Weigand

E-Mail email hidden; JavaScript is required
website: Weigand Lab

Technische Universität Darmstadt
Fachbereich Biologie, B2|03 E27
Schnittspahnstraße 10
64287 Darmstadt
Phone +49 (0)6151-16-22005
Julia Weigand

Personal data
Date/Place of birth 01/23/1981 in Nürnberg


2000-2005 Diploma (Biology), Friedrich-Alexander-University Erlangen
2006-2009 Ph.D. (Biology) with Prof. Dr. B. Suess, Friedrich-Alexander-University Erlangen and Goethe-University Frankfurt/M.
2010-2011 Postdoctoral Fellow with Prof. Dr. S. Dimmeler, Johann Wolfgang Goethe-University Frankfurt/M.

Research Experience

2012- Independent work as Habilitand, Goethe University Frankfurt/M. and Technical University Darmstadt

Honors and Awards

2013- Own position funded by the Else Kröner-Fresenius-Stiftung
2010-2011 Postdoctoral Fellowship of the Excellence Cluster Cardiopulmonary-System (ECCPS)
2010 Best Ph.D. thesis at the Institute of Molecular Biosciences 2009/10, Johann Wolfgang Goethe-University Frankfurt/M.

Most relevant publications (2009-2014)

Krstic I, Frolow O, Sezer D, Endeward B, Weigand JE, Suess B, Engels JW & Prisner TF (2010) PELDOR spectroscopy reveals preorganization of the neomycin-responsive riboswitch tertiary structure. J. Am. Chem. Soc. 132: 1454-5. Available at http://dx.doi.org/10.1021/ja9077914.
Duchardt-Ferner E, Weigand JE, Ohlenschläger O, Schmidtke SR, Suess B & Wöhnert J (2010) Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch. Angew. Chem. Int. Ed. 49: 6216-9. Available at http://dx.doi.org/10.1002/anie.201001339.
Wunnicke D, Strohbach D, Weigand JE, Appel B, Feresin E, Suess B, Müller S & Steinhoff HJ (2011) Ligand-induced conformational capture of a synthetic tetracycline riboswitch revealed by pulse EPR. RNA 17: 182-8. Available at http://dx.doi.org/10.1261/rna.2222811.
Weigand JE, Schmidtke SR, Will TJ, Duchardt-Ferner E, Hammann C, Wöhnert J & Suess B (2011) Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity. Nucleic Acids Res. 39: 3363-72. Available at http://dx.doi.org/10.1093/nar/gkq946.
Förster U, Weigand JE, Trojanowski P, Suess B & Wachtveitl J (2012) Conformational dynamics of the tetracycline-binding aptamer. Nucleic Acids Res. 40: 1807-17. Available at http://dx.doi.org/10.1093/nar/gkr835.
Weigand JE*, Boeckel JN, Gellert P & Dimmeler S (2012) Hypoxia-induced alternative splicing in endothelial cells. PLoS One 7: e42697. Available at http://dx.doi.org/10.1371/journal.pone.0042697 *corresponding author.
Heinrich EM, Wagner J, Krüger M, John D, Uchida S, Weigand JE, Suess B & Dimmeler S (2013) Regulation of miR-17-92a cluster processing by the microRNA binding protein SND1. FEBS Lett. 587: 2405-11. Available at http://dx.doi.org/10.1016/j.febslet.2013.06.008.
Demolli S, Geist MM, Weigand JE, Matschiavelli N, Suess B & Rother M (2014) Development of beta -Lactamase as a Tool for Monitoring Conditional Gene Expression by a Tetracycline-Riboswitch in Methanosarcina acetivorans. Archaea 2014: 725610. Available at http://dx.doi.org/10.1155/2014/725610.
Gottstein-Schmidtke SR, Duchardt-Ferner E, Groher F, Weigand JE, Gottstein D, Suess B & Wöhnert J (2014) Building a stable RNA U-turn with a protonated cytidine. RNA 20: 1163-72. Available at http://dx.doi.org/10.1261/rna.043083.
Weigand JE, Gottstein-Schmidtke SR, Demolli S, Groher F, Duchardt-Ferner E, Wöhnert J & Suess B (2014) Sequence elements distal to the ligand binding pocket modulate the efficiency of a synthetic riboswitch. Chembiochem 15: 1627-37. Available at http://dx.doi.org/10.1002/cbic.201402067.