B15: Andreas Krueger

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Institute for Molecular Medicine
Universitätsklinikum, Building 75, 1st floor
Sandhofstrasse 2–4
60590 Frankfurt am Main / Niederrad
Phone +49 (0)69-6301-87860
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Curriculum Vitae

Name                         Prof. Dr. Andreas Krueger

Date of Birth        20th November 1973

Scientific Education:

2011                Habilitation in Immunology, Hannover Medical School

1999 – 2002     PhD (Dr. rer. nat.) in Biochemistry and Immunology, German Cancer Research Center, Heidelberg, Germany (Supervisor: Peter H. Krammer)

1994 – 1999     Diploma in Biochemistry, University of Hannover, Germany

1995 – 2003     Studies in Philosophy and German Literature, University of Hagen, Germany

Academic Appointments:

2015 –              Professor, Molecular Immunology, Institute for Molecular Medicine, Goethe-University Frankfurt am Main, Germany

2014 – 2015     Professor, Regenerative Immunology, Institute for Immunology and Cluster of Excellence “REBIRTH”, Hannover Medical School, Germany

2013 – 2014     Group Leader, Regenerative Immunology, Institute for Immunology and Cluster of Excellence “REBIRTH”, Hannover Medical School, Germany

2008 – 2013     Research Group Leader, Emmy-Noether Program (German Research Foundation, DFG), Institute for Immunology and Cluster of Excellence “REBIRTH”, Hannover Medical School, Germany

2007 – 2013     Junior Group Leader, Cluster of Excellence “REBIRTH” and Institute for Immunology, Hannover Medical School, Germany

2003 – 2007     Research Fellow, Dept. of Pathology, Harvard Medical School, and Dept. of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA, USA (Mentor: Harald von Boehmer)

2002 – 2003     Postdoctoral Fellow, Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany (Mentor: Peter H. Krammer)

Awards:

2010                 „Excellence Award“,Cluster of Excellence “REBIRTH”

2004 – 2006     Lymphoma Research Foundation Fellowship

1995 – 1999       Scholarship of the Ev. Studienwerk Villigst (Scholarship organization of the Protestant Churches in Germany)

Academic Activities:

  • Executive Board of PhD Program “Regenerative Sciences”
  • Reviewer for DFG, various European funding agencies and multiple scientific journals

Major Scientific Achievements:

  • Quantitation of progenitor niche size in the thymus
  • Identification of miR-181 as master regulator of NKT cell differentiation
  • Identification of a novel mode of cross-talk of B cells and DCs
  • Definition of minimal requirements for thymus seeding
  • Identification of an adult T-lineage committed progenitor population

10 Important Publications:

Regelin M, Blume J, Pommerencke J, Vakilzadeh R, Witzlau K, Łyszkiewicz M, Ziętara N, Saran N, Schambach A, Krueger A (2015). Responsiveness of developing T cells to IL-7 signals is sustained by miR-17∼92. J Immunol 195:4832-40.

Ziętara N, Łyszkiewicz M, Puchałka J, Witzlau K, Förster R, Pabst O, Prinz I, Krueger A (2015). Multicongenic fate mapping quantification of dynamics of thymus colonization. J Exp Med 212:1589-1601.

Łyszkiewicz M, Ziętara N, Föhse L, Puchałka J, Diestelhorst J, Witzlau J, Prinz I, Schambach A, Krueger A (2015). Limited niche availability suppresses murine intrathymic dendritic-cell development from non-committed progenitors. Blood 125(3):457-64.

Ziętara N, Łyszkiewicz M, Witzlau K, Naumann R, Hurwitz R, Langemeier J, Bohne J, Sandrock I, Ballmaier M, Weiss S, Prinz I*, and Krueger A* (2013). Critical role for miR-181a/b-1 in agonist selection of invariant natural killer T cells. Proc. Natl. Acad. Sci. USA, 110:7407-7412. * shared senior authorship.

Ziętara N, Łyszkiewicz M, Puchałka J, Gutierrez MG, Pei G, Lienenklaus S, Hobeika E, Reth, M, Martins Dos Santos VAP, Krueger A*, and Weiss S* (2013). Immunoglobulins drive terminal maturation of splenic dendritic cells. Proc. Natl. Acad. Sci. USA, 110:2282-2287. * shared senior authorship.

Saran N, Łyszkiewicz M, Pommerencke J, Witzlau K, Vakilzadeh R, Ballmaier M, von Boehmer H, Krueger A (2010). Multiple extra-thymic precursors contribute to T cell development with different kinetics. Blood 115: 1137-44.

Krueger A, von Boehmer H (2007). Identification of a T lineage-committed progenitor in adult blood. Immunity 26: 105-16.

Krueger A, Garbe AI, von Boehmer H (2006). Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands. J Exp Med 203: 1977-84.

Garbe AI*, Krueger A*, Gounari F, Zuniga-Pflucker JC, von Boehmer H (2006). Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate. J Exp Med 203: 1579-90. * Equal contribution.

Eichhorst ST*, Krueger A*, Müerköster S, Fas SC, Golks A, Gruetzner U, Schubert L, Opelz C, Bilzer M, Gerbes AL, Krammer PH (2004). Suramin inhibits death receptor-induced apoptosis in vitro and fulminant apoptotic liver damage in mice. Nat Med 10: 602-9. * Equal contribution.