B17: Helge Bode

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Institut für Molekulare Biowissenschaften
N100 / Raum Nr. 2.05a
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 9
60438 Frankfurt am Main, Germany
Phone +49 69 798-29785
Homepage AK Bode

Personal data

Date/Place of birth 02/03/1973 in Eschwege

Education

1992-1997 Diploma (Chemistry), Georg-August University Göttingen
1994-2001 Diploma (Biology), Georg-August University Göttingen
1997-2000 Ph.D. (Chemistry) with Prof. Dr. Axel Zeeck, Georg-August University Göttingen
2000-2001 Postdoctoral Fellow with Prof. Dr. A. Zeeck, Georg-August University Göttingen
2001-2002 Postdoctoral Fellow with Prof. Dr. Rolf Müller, Gesellschaft für Biotechnologische Forschung (now Helmholtz Zentrum für Infektionsforschung) in Braunschweig
2002-2003 Postdoctoral Fellow with Prof. Dr. Dale Kaiser, Stanford University, USA

Research Experience

2004-2005 Juniorprofessor for Natural Product Biotechnology, Saarland University, Saarbrücken (associated to Prof. Dr. Rolf Müller)
2006-2010 Group leader within the Emmy Noether Program (DFG), Saarland University (Saarbrücken) and Johann Wolfgang Goethe-University Frankfurt/M.
2008-2017 Merck endowed chair for Molecular Biotechnology, Department of Biosciences, Johann Wolfgang Goethe-University Frankfurt/M.
Since 2018 Professor for Molecular Biotechnology, Department of Biosciences, Johann Wolfgang Goethe-University Frankfurt/M.

Honors and Awards

2016 1. Prize at the Goethe Innovationsforum 2016 (together with Dr. Kenan Bozhüyük, Dr. Darko Kresovic, Florian Fleischhacker; 10.000 €; Goethe University and Handelsblatt) for the business concept Rhabdotec based on NRPS engineering
2013-2018 Starting grant (consolidator) from the European Research Council (ERC)
2007 Award of the PHÖNIX-Price for Pharmaceutical Biotechnology together with P. Meiser and R. Müller for: P. Meiser, H.B. Bode, R. Müller*, Proc. Natl. Acad. Sci. USA 2006, 103, 19128-33.
2007 Award of the DECHEMA Prize for Natural product Research 2007
2006-2010 Group leader within the Emmy Noether-Program of the DFG
2001-2003 Research fellowship from the DFG (BO 1834/1-1)

Most relevant publications (2013-2018)

 
Hacker C, Cai X, Kegler C, Zhao L, Weickhmann AK, Wurm JP, Bode HB, Wöhnert J (2018) Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS. Nat. Comm. accepted. DOI: 10.1038/s41467-018-06712-1.
Bozhüyük KAJ, Fleischhacker F, Linck A, Wesche F, Tietze A, Niesert CP, Bode HB (2018) De novo design and engineering of non-ribosomal peptide synthetases. Nat. Chem. 10: 275-281. DOI: 10.1038/nchem.2890.
Tobias NJ, Linck A, Bode HB (2018) Natural Product Diversification Mediated by Alternative Transcriptional Starting. Angew. Chem. Int. Ed. 57: 5699-5702. DOI: 10.1002/anie.201713199.
Tobias NJ, Wolff H, Djahanschiri B, Grundmann F, Kronenwerth M, Shi YM, Simonyi S, Grün P, Shapiro-Ilan D, Pidot SJ, Stinear TP, Ebersberger I, Bode HB (2017) Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nat. Microbiol. 2: 1676-1685. DOI: 10.1038/s41564-017-0039-9.
Cai X, Nowak S, Wesche F, Bischoff I, Kaiser M, Fürst R, Bode HB (2017) Entomopathogenic bacteria use multiple mechanisms for bioactive peptide library design. Nat. Chem. 9: 379-386. DOI: 10.1038/nchem.2671.
Tobias NJ, Heinrich AK, Eresmann H, Wright PR, Neubacher N, Backofen R, Bode HB (2017) Photorhabdus-nematode symbiosis is dependent on hfq-mediated regulation of secondary metabolites. Environ. Microbiol. 19: 119-129. DOI: 10.1111/1462-2920.13502.
Schimming O, Challinor VL, Tobias NJ, Adihou H, Grün P, Pöschel L, Richter C, Schwalbe H, Bode HB (2015) Structure, Biosynthesis, and Occurence of Bacterial Pyrrolizidine alkaloids. Angew. Chem. Int. Ed. 54: 12702-5. DOI: 10.1002/anie.201504877.
Brameyer S, Kresovic D, Bode HB, Heermann R (2015) Dialkylresorcinols as bacterial signaling molecules. Proc. Natl. Acad. Sci. U S A. 112: 572-7. DOI: 10.1073/pnas.1417685112.
Lorenzen W, Ahrendt T, Bozhüyük KA, Bode HB (2014) A multifunctional enzyme is involved in bacterial ether lipid biosynthesis. Nat. Chem. Biol. 10: 425-7. DOI: 10.1038/nchembio.1526.
Brachmann AO, Brameyer S, Kresovic D, Hitkova I, Kopp Y, Manske C, Schubert K, Bode HB, Heermann R (2013) Pyrones as bacterial signaling molecules. Nat. Chem. Biol. 9: 573-8. DOI: 10.1038/nchembio.1295.