B2: Stefanie Dimmeler

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Institut für Kardiovaskuläre Regeneration
Goethe-University Frankfurt am Main
Theodor-Stern-Kai 7
60438 Frankfurt am Main, Germany
Phone +49 (0)69 6301-7440
Homepage Institute of Cardiovascular Regeneration

Personal data

1986-1991 MSc in Biology at the University of Konstanz, Germany
1990-1991 Diploma, Department of Biological Chemistry, University of Konstanz
1991-1993 PhD (Dr. rer. nat.) at the Department of Biological Chemistry (Prof. V. Ullrich), University of Konstanz

Research Experience

1992-1995 Postdoctoral Fellow, Department of Experimental Surgery, University of Cologne, Cologne, Germany
1995-1997 Postdoctoral Fellow, Department of Molecular Cardiology, Goethe University, Frankfurt, Germany
1998-2000 Associate Professor, Head of Department of Molecular Cardiology, Goethe University, Frankfurt, Germany
2000-2008 Full Professor (C3), Head of Department of Molecular Cardiology, Goethe University, Frankfurt, Germany
Since 2006 Visiting Professor New York Medical College
2007 Edmond Hustinx Chair, University of Maastricht
Since March 2008 Full Professorship (W3), Director Institute of Cardiovascular Regeneration, Center for Molecular Medicine, University Frankfurt, Germany
Since 2008 Member of the German Ethical Committee (Deutscher Ethikrat)

Honors and Awards

2014 Madrid Award for Cell therapy and Cardiovascular Regeneration
2014 “Highly Cited Researchers 2014” (selected by Thomson Reuters)
2010 Award of the GlaxoSmithKline Foundation
2008 Science4life Award
2007 Ernst Jung Award 2007
2006 FEBS Anniversary Prize 2006
2006 Basic Science Lecture and Silver Medal of the European Society of Cardiology
2005 Leibniz Award of the Deutsche Forschungsmeinschaft (DFG)
2005 George E. Brown Memorial Lecture at the Scientific Session of the AHA 2005
2004 Forssmann Award by the University Bochum
2002 Alfried Krupp-Award by the Alfried Krupp foundation
1999 Award of the German Cardiac Society (Fraenkel-Preis)
1998 Award of the Herbert and Hedwig Eckelmann-Foundation
1997 Habilitationsstipendium of the German Research Foundation (DFG)
1994 Fritz-Külz-Award of the German Association of Pharmacology and Toxicology
1992 Boehringer Ingelheim Fonds Fellowship
1991 Award of the Foundation of German Sciences

Ten most relevant publications (2009-2014)

Michalik KM, You X, Manavski Y, Doddaballapur A, Zörnig M, Braun T, John D, Ponomareva Y, Chen W, Uchida S, Boon RA & Dimmeler S (2014) Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth. Circ. Res. 114: 1389–97. Available at http://dx.doi.org/10.1161/CIRCRESAHA.114.303265.
Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJG, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, et al (2013) MicroRNA-34a regulates cardiac ageing and function. Nature 495: 107–10. Available at http://dx.doi.org/10.1038/nature11919.
Ohtani K, Zhao C, Dobreva G, Manavski Y, Kluge B, Braun T, Rieger MA, Zeiher AM & Dimmeler S (2013) Jmjd3 controls mesodermal and cardiovascular differentiation of embryonic stem cells. Circ. Res. 113: 856–62. Available at: http://dx.doi.org/10.1161/CIRCRESAHA.113.302035.
Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJG, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA & Dimmeler S (2012) Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat. Cell Biol. 14: 249–56. Available at http://dx.doi.org/10.1038/ncb2441.
Iekushi K, Seeger F, Assmus B, Zeiher AM & Dimmeler S (2012) Regulation of cardiac microRNAs by bone marrow mononuclear cell therapy in myocardial infarction. Circulation 125: 1765–73, S1–7. Available at: http://dx.doi.org/10.1161/CIRCULATIONAHA.111.079699.
Urbich C, Kaluza D, Frömel T, Knau A, Bennewitz K, Boon RA, Bonauer A, Doebele C, Boeckel J-N, Hergenreider E, Zeiher AM, Kroll J, Fleming I & Dimmeler S (2012) MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. Blood 119: 1607–16. Available at http://dx.doi.org/10.1182/blood-2011-08-373886.
Ohtani K, Vlachojannis GJ, Koyanagi M, Boeckel J-N, Urbich C, Farcas R, Bonig H, Marquez VE, Zeiher AM & Dimmeler S (2011) Epigenetic regulation of endothelial lineage committed genes in pro-angiogenic hematopoietic and endothelial progenitor cells. Circ. Res. 109: 1219–29. Available at: http://dx.doi.org/10.1161/CIRCRESAHA.111.247304.
Boon RA, Seeger T, Heydt S, Fischer A, Hergenreider E, Horrevoets AJG, Vinciguerra M, Rosenthal N, Sciacca S, Pilato M, van Heijningen P, Essers J, Brandes RP, Zeiher AM & Dimmeler S (2011) MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ. Res. 109: 1115–9. Available at: http://dx.doi.org/10.1161/CIRCRESAHA.111.255737.
Doebele C, Bonauer A, Fischer A, Scholz A, Reiss Y, Urbich C, Hofmann W-K, Zeiher AM & Dimmeler S (2010) Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 115: 4944–50. Available at: http://dx.doi.org/10.1182/blood-2010-01-264812.
Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher AM & Dimmeler S (2009) MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 324: 1710–3. Available at http://dx.doi.org/10.1126/science.1174381.