B5: Achilleas Frangakis

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Exzellenzcluster Makromolekulare Komplexe
Institut für Biophysik
Goethe-Universität Frankfurt am Main
Max-von-Laue-Str. 1
60438 Frankfurt am Main, Germany
Phone +49 (0)69 798-46462
Homepage Frangakis Group

Personal data

1992-1997 Diploma (Electrical Engineering and Information Theory), Technical University of Munich
1998-2001 Ph.D. (Physics) with Prof. W. Baumeister, Technical University of Munich
2001-2002 Postdoctoral Fellow with Prof. W. Baumeister, Max Planck Institute of Biochemistry, Munich

Research Experience

2002-2003 Beckmann research fellow, California Institute of Technology (Caltech)
2004-2008 Group leader for cryo-electron tomography, European Molecular Biology Laboratory in Heidelberg (EMBL)
since 2008 Full Professor (W3) at the Department of Physics, Goethe University Frankfurt/M.
since 2008 Cluster of Excellence “Macromolecular Complexes” Investigator, Goethe University Frankfurt/M.

Honors and Awards

1998 Scholarship from A. S. Onassis Public Benefit Foundation
1999 Ph.D. scholarship from the Max Planck Society
2001 Beckman research young investigators fellowship
2009 ERC starting grants

Ten most relevant publications (2009-2014)

Yu Z & Frangakis AS (2014) M-free: Scoring the reference bias in sub-tomogram averaging and template matching. J. Struct. Biol. Available at http://dx.doi.org/10.1016/j.jsb.2014.05.007.
Perkovic M, Kunz M, Endesfelder U, Bunse S, Wigge C, Yu Z, Hodirnau V-V, Scheffer MP, Seybert A, Malkusch S, Schuman EM, Heilemann M & Frangakis AS (2014) Correlative Light- and Electron Microscopy with chemical tags. J. Struct. Biol. 186: 205–13. Available at http://dx.doi.org/10.1016/j.jsb.2014.03.018.
Geiss CP, Keramisanou D, Sekulic N, Scheffer MP, Black BE & Frangakis AS (2014) CENP-A arrays are more condensed than canonical arrays at low ionic strength. Biophys. J. 106: 875–82. Available at http://dx.doi.org/10.1016/j.bpj.2014.01.005.
Scheffer MP, Eltsov M, Bednar J & Frangakis AS (2012) Nucleosomes stacked with aligned dyad axes are found in native compact chromatin in vitro. J. Struct. Biol. 178: 207–14. Available at http://dx.doi.org/10.1016/j.jsb.2011.11.020.
Saibil HR, Seybert A, Habermann A, Winkler J, Eltsov M, Perkovic M, Castaño-Diez D, Scheffer MP, Haselmann U, Chlanda P, Lindquist S, Tyedmers J & Frangakis AS (2012) Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures. Proc. Natl. Acad. Sci. U. S. A. 109: 14906–11. Available at http://dx.doi.org/10.1073/pnas.1211976109.
Yu Z & Frangakis AS (2011) Classification of electron sub-tomograms with neural networks and its application to template-matching. J. Struct. Biol. 174: 494–504. Available at http://dx.doi.org/10.1016/j.jsb.2011.02.009.
Scheffer MP, Eltsov M & Frangakis AS (2011) Evidence for short-range helical order in the 30-nm chromatin fibers of erythrocyte nuclei. Proc. Natl. Acad. Sci. U. S. A. 108: 16992–7. Available at http://dx.doi.org/10.1073/pnas.1108268108.
Al-Amoudi A, Castaño-Diez D, Devos DP, Russell RB, Johnson GT & Frangakis AS (2011) The three-dimensional molecular structure of the desmosomal plaque. Proc. Natl. Acad. Sci. U. S. A. 108: 6480–5. Available at http://dx.doi.org/10.1073/pnas.1019469108.
Castaño-Díez D, Scheffer M, Al-Amoudi A & Frangakis AS (2010) Alignator: a GPU powered software package for robust fiducial-less alignment of cryo tilt-series. J. Struct. Biol. 170: 117–26. Available at http://dx.doi.org/10.1016/j.jsb.2010.01.014.
Kühner S, van Noort V, Betts MJ, Leo-Macias A, Batisse C, Rode M, Yamada T, Maier T, Bader S, Beltran-Alvarez P, Castaño-Diez D, Chen W-H, Devos D, Güell M, Norambuena T, Racke I, Rybin V, Schmidt A, Yus E, Aebersold R, Herrmann R, Böttcher B, Frangakis AS, Russell RB, Serrano L, Bork P, Gavin AC. (2009) Proteome organization in a genome-reduced bacterium. Science 326: 1235–40. Available at: http://dx.doi.org/10.1126/science.1176343.