A1: Harald Schwalbe (CRC Speaker)

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Institut für Organische Chemie und Chemische Biologie
N160 / 3.OG / Raum Nr. 314
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 7
60438 Frankfurt am Main, Germany
Phone +49 (0)69 798-29130
Homepage Schwalbe Group


Personal data
 
Date/Place of birth 03/26/1966 in Frankfurt am Main
 

Education

 
1985-1990 Diploma (Chemistry), Goethe University Frankfurt/M.
1990-1993 Ph.D. (Chemistry) with Prof. Dr. C. Griesinger, Goethe University Frankfurt/M.
1993-1995 Postdoctoral Fellow with Prof. Dr. C. M. Dobson, Oxford, UK
 

Research Experience

 
1995-1999 Independent work as Habilitand, Goethe University Frankfurt/M., Mentor: Prof. Dr. C. Griesinger
1999-2002 Assistant/Associate Professor at MIT/USA
2002 Full Professor (C4) for Organic Chemistry, Goethe University Frankfurt/M.

Honors and Awards

 
2014 “Scientist of the Year” of the Frankfurt Kassel Stiftung
2006 1822-Award for Best Teaching at Goethe University
2002 Vertrauensdozent of Studienstiftung des Deutschen Volkes
2002 Editorial Board ChemBioChem
2001 Pew Scholar for Biomedical Sciences
2001 Alfred P. Sloan Fellow
2000 Karl-Winnacker-Preis
1999 Gerhard-Hess-Preis der DFG
1996 Liebig Fellowship (Fonds der Chemischen Industrie)
1993-1995 Human Capital and Mobility Stipend
1993 Studienabschluss-Stipendium (Fonds der Chemischen Industrie)
1986-1990 Stipendiat of Studienstiftung des Deutschen Volkes
 

Ten most relevant publications (2009-2014)

 
Hänsel R, Foldynová-Trantírková S, Löhr F, Buck J, Bongartz E, Bamberg E, Schwalbe H, Dötsch V & Trantírek L (2009) Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy. J. Am. Chem. Soc. 131: 15761–8. Available at http://dx.doi.org/10.1021/ja9052027.
 
Rinnenthal J, Klinkert B, Narberhaus F & Schwalbe H (2010) Direct observation of the temperature-induced melting process of the Salmonella fourU RNA thermometer at base-pair resolution. Nucleic Acids Res. 38: 3834–47. Available at http://dx.doi.org/10.1093/nar/gkq124.
 
Manoharan V, Fürtig B, Jäschke A & Schwalbe H (2009) Metal-induced folding of Diels-Alderase ribozymes studied by static and time-resolved NMR spectroscopy. J. Am. Chem. Soc. 131: 6261–70. Available at http://dx.doi.org/10.1021/ja900244x.
 
Cao S, Fürtig B, Schwalbe H & Chen S-J (2010) Folding kinetics for the conformational switch between alternative RNA structures. J. Phys. Chem. B 114: 13609–15. Available at http://dx.doi.org/10.1021/jp107912s.
 
Fürtig B, Wenter P, Pitsch S & Schwalbe H (2010) Probing mechanism and transition state of RNA refolding. ACS Chem. Biol. 5: 753–65. Available at http://dx.doi.org/10.1021/cb100025a.
 
Cherepanov A V, Glaubitz C & Schwalbe H (2010) High-resolution studies of uniformly 13C,15N-labeled RNA by solid-state NMR spectroscopy. Angew. Chem. Int. Ed. 49: 4747–50. Available at http://dx.doi.org/10.1002/anie.200906885.
 
Nozinovic S, Richter C, Rinnenthal J, Fürtig B, Duchardt-Ferner E, Weigand JE & Schwalbe H (2010) Quantitative 2D and 3D Gamma-HCP experiments for the determination of the angles alpha and zeta in the phosphodiester backbone of oligonucleotides. J. Am. Chem. Soc. 132: 10318–29. Available at http://dx.doi.org/10.1021/ja910015n.
 
Lieblein AL, Krämer M, Dreuw A, Fürtig B & Schwalbe H (2012) The nature of hydrogen bonds in cytidine···H+···cytidine DNA base pairs. Angew. Chem. Int. Ed. 51: 4067–70. Available at http://dx.doi.org/10.1002/anie.201200549.
 
Schlepckow K & Schwalbe H (2013) Molecular mechanism of prion protein oligomerization at atomic resolution. Angew. Chem. Int. Ed. 52: 10002–5. Available at http://dx.doi.org/10.1002/anie.201305184.
 
C. Herbert, U. Schieborr, K. Saxena, J. Juraszek, F. De Smet, C. Alcouffe, M. Bianciotto, G. Saladino, D. Sibrac, D. Kudlinzki, S. Sreeramulu, A. Brown, P. Rigon, J.-P. Herault, G. Lassalle, T.L. Blundell, F. Rousseau, A. Gils, J. Schymkowitz, P. Tompa, J.-M. Herbert, P. Carmeliet, F.L. Gervasio, H. Schwalbe, F. Bono (2013) Molecular mechanism of SSR128129E, an extracellularly acting, small molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell 23: 489-501. Available at http://dx.doi.org/10.1016/j.ccr.2013.02.018.
 
Stehle J, Silvers R, Werner K, Chatterjee D, Gande S, Scholz F, Dutta A, Wachtveitl J, Klein-Seetharaman J & Schwalbe H (2014) Characterization of the simultaneous decay kinetics of metarhodopsin states II and III in rhodopsin by solution-state NMR spectroscopy. Angew. Chem. Int. Ed. 53: 2078–84. Available at http://dx.doi.org/10.1002/anie.201309581.