A2: Beatrix Suess

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Technische Universität Darmstadt
Fachbereich Biologie, B2|03 064
Schnittspahnstraße 10
64287 Darmstadt
Phone +49 (0)6151-16-75855
Homepage Suesslab

Personal data

Date/Place of birth 01/23/1971 in Sonneberg/Thür.

Education

1989-1994 Diploma (Biologie), Universities of Greifswald and Erlangen, Germany
1995-1998 Ph.D. (Biology), University of Erlangen, Germany
1999-2000 Postdoctoral Fellow with Prof. Dr. Hillen, University of Erlangen

Research Experience

2001-2006 Habilitation in Microbiology, University of Erlangen
2000 Research Fellow with Prof. Dr. Renee Schroeder, University of Vienna, Austria
2006 Research Fellow with Prof. Dr. Ron Breaker, Yale University, CT, USA
2007 Aventis Foundation Professorship (W2) for Chemical Biology, Goethe University Frankfurt

Honors and Awards

2014  Board of Directors: International Society of Aptamers
2010 Associated Editor: RNA Biology
2010 Associated Editor: Frontiers in Inflammation Pharmacology
2007 Emmy-Noether-Habilitationspreis der Universität Erlangen
2005-2007 HWP Fellowship (Habilitationsstipendium)
2000-2003 Bayerischer Habilitationsförderpreis
1994-1996 Boehringer Ingelheim Fonds Fellowship

Ten most relevant publications (2009-2014)

 
Weigand JE, Gottstein-Schmidtke SR, Demolli S, Groher F, Duchardt-Ferner E, Wöhnert J and Suess B (2014) Sequence elements distal to the ligand binding pocket tune the efficiency of a synthetic riboswitch. ChemBioChem 2014 15: 1627-37. Available at http://dx.doi.org/10.1002/cbic.201402067.
 
Meitert J, Aram R, Wiesemann K, Weigand JE & Suess B (2013) Monitoring the expression level of coding and non-coding RNAs using a TetR inducing aptamer tag. Bioorg. Med. Chem. 21: 6233–8. Available at http://dx.doi.org/10.1016/j.bmc.2013.07.035.
 
Rudolph MM, Vockenhuber M-P & Suess B (2013) Synthetic riboswitches for the conditional control of gene expression in Streptomyces coelicolor. Microbiology 159: 1416–22. Available at http://dx.doi.org/10.1099/mic.0.067322-0.
 
Langner JS, Fuchs N V, Hoffmann J, Wittmann A, Brutschy B, Löwer R & Suess B (2012) Biochemical analysis of the complex between the tetrameric export adapter protein Rec of HERV-K/HML-2 and the responsive RNA element RcRE pck30. J. Virol. 86: 9079–87. Available at http://dx.doi.org/10.1128/JVI.00121-12.
 
Förster U, Weigand JE, Trojanowski P, Suess B & Wachtveitl J (2012) Conformational dynamics of the tetracycline-binding aptamer. Nucleic Acids Res. 40: 1807–17. Available at http://dx.doi.org/10.1093/nar/gkr835.
 
Steber M, Arora A, Hofmann J, Brutschy B & Suess B (2011) Mechanistic basis for RNA aptamer-based induction of TetR. Chembiochem 12: 2608–14. Available at http://dx.doi.org/10.1002/cbic.201100503.
 
Wittmann A & Suess B (2011) Selection of tetracycline inducible self-cleaving ribozymes as synthetic devices for gene regulation in yeast. Mol. Biosyst. 7: 2419–27. Available at http://dx.doi.org/10.1039/c1mb05070b.
 
Weigand JE, Schmidtke SR, Will TJ, Duchardt-Ferner E, Hammann C, Wöhnert J & Suess B (2011) Mechanistic insights into an engineered riboswitch: a switching element which confers riboswitch activity. Nucleic Acids Res. 39: 3363–72. Available at http://dx.doi.org/10.1093/nar/gkq946.
 
Duchardt-Ferner E, Weigand JE, Ohlenschläger O, Schmidtke SR, Suess B & Wöhnert J (2010) Highly modular structure and ligand binding by conformational capture in a minimalistic riboswitch. Angew. Chem. Int. Ed. 49: 6216–9. Available at http://dx.doi.org/10.1002/anie.201001339.
 
Krstić I, Frolow O, Sezer D, Endeward B, Weigand JE, Suess B, Engels JW & Prisner TF (2010) PELDOR spectroscopy reveals preorganization of the neomycin-responsive riboswitch tertiary structure. J. Am. Chem. Soc. 132: 1454–5. Available at http://dx.doi.org/10.1002/ange.200805152.