A6 & B11: Alexander Heckel

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Frankfurt Institute for Molecular Life Sciences (FMLS)
Goethe-University Frankfurt am Main
Max-von-Laue-Str. 15
60438 Frankfurt am Main, Germany
Phone +49 (0)69 763-42505
Homepage AK Heckel

Personal data

Date/Place of birth 02/26/1972 in Lindau (B)


1992-1997 Diploma (Chemistry), University of Constance, Germany
1997-2001 Ph.D. (Chemistry) with Prof. D. Seebach, ETH Zurich, Switzerland
2001-2003 Postdoctoral Fellow with Prof. P. B. Dervan, Caltech, USA

Research Experience

2003-2007 Independent work as Liebig- and Emmy Noether-Fellow, University of
Bonn – Mentor: Prof. M. Famulok
2007 Professorship (W2) for Chemical Biology and Medicinal Chemistry, University of Frankfurt

Honors and Awards

2010 Award for Excellence in Teaching of the Department
2009 Award for Excellence in Teaching of the Department
2008 Dozentenstipendium (Fonds der Chemischen Industrie)
2008 Grammaticakis-Neumann Award (Swiss Chemical Society)
2006- Emmy Noether Fellowship
2006 Thieme Journal Award
2003-2006 Liebig Fellowship (Fonds der Chemischen Industrie)
2001-2003 Feodor Lynen Fellowship (Alexander von Humboldt-Foundation)
1998-1999 Kekulé Fellowship (Fonds der Chemischen Industrie)
1997 Award for best Diploma in Chemistry
1992-1996 Bayerisches Hochbegabten-Stipendium

Ten most relevant publications (2009-2014)

Gatterdam V, Ramadass R, Stoess T, Fichte MAH, Wachtveitl J, Heckel A & Tampé R (2014) Three-dimensional protein networks assembled by two-photon activation. Angew. Chem. Int. Ed. 53: 5680–4. Available at http://dx.doi.org/10.1002/anie.201309930.
Steinert HS, Schäfer F, Jonker HRA, Heckel A & Schwalbe H (2014) Influence of the absolute configuration of npe-caged cytosine on DNA single base pair stability. Angew. Chem. Int. Ed. 53: 1072–5. Available at http://dx.doi.org/10.1002/anie.201307852.
Schäfer F, Wagner J, Knau A, Dimmeler S & Heckel A (2013) Regulating angiogenesis with light-inducible AntimiRs. Angew. Chem. Int. Ed. 52: 13558–61. Available at http://dx.doi.org/10.1002/anie.201307502.
Rohrbach F, Schäfer F, Fichte MAH, Pfeiffer F, Müller J, Pötzsch B, Heckel A & Mayer G (2013) Aptamer-guided caging for selective masking of protein domains. Angew. Chem. Int. Ed. 52: 11912–5. Available at http://dx.doi.org/10.1002/anie.201306686.
Brieke C & Heckel A (2013) Spiropyran photoswitches in the context of DNA: synthesis and photochromic properties. Chem. Eur. J. 19: 15726–34. Available at http://dx.doi.org/10.1002/chem.201302640.
Kohl-Landgraf J, Braun M, Özçoban C, Gonçalves DPN, Heckel A & Wachtveitl J (2012) Ultrafast dynamics of a spiropyran in water. J. Am. Chem. Soc. 134: 14070–7. Available at http://dx.doi.org/10.1021/ja304395k.
Gatterdam V, Stoess T, Menge C, Heckel A & Tampé R (2012) Caged glutathione – triggering protein interaction by light. Angew. Chem. Int. Ed. 51: 3960–3. Available at http://dx.doi.org/10.1002/anie.201108073.
Schmidt TL & Heckel A (2011) Construction of a structurally defined double-stranded DNA catenane. Nano Lett. 11: 1739–42. Available at http://dx.doi.org/10.1021/nl200303m.
Ackermann D, Schmidt TL, Hannam JS, Purohit CS, Heckel A & Famulok M (2010) A double-stranded DNA rotaxane. Nat. Nanotechnol. 5: 436–42. Available at http://dx.doi.org/10.1038/nnano.2010.65.
Buff MCR, Schäfer F, Wulffen B, Müller J, Pötzsch B, Heckel A & Mayer G (2010) Dependence of aptamer activity on opposed terminal extensions: improvement of light-regulation efficiency. Nucleic Acids Res. 38: 2111–8. Available at http://dx.doi.org/10.1093/nar/gkp1148.