A06 – Alexander Heckel

Light-responsive riboswitches and miRNA activity

In project A6, we will implement new ways to regulate RNA with light as external stimulus. For that, we will develop light-responsive riboswitches using different approaches. Using caged antimiRs, we will regulate wound healing with light in a mouse model. Furthermore, we will develop new ways to regulate RNA hybridization with light using reversible photoswitches and prepare differently labelled RNAs for several spectroscopically oriented projects of this CRC.

Team

Alexander Heckel (Principal Investigator)
Josefine Kahlstatt
Thomas Halbritter
Patricia Müller