B13 – Michaela Müller-McNicoll & Katharina Zarnack

Comprehensive functional analysis of SR proteins and their roles in alternative polyadenylation and nuclear splicing surveillance

Eukaryotic mRNAs recruit numerous RNA-binding proteins, which form large mRNA ribonucleoprotein particles (mRNPs) and influence mRNA processing and maturation. Here, we investigate the role of a family of nuclear RBPs, called SR proteins, in alternative polyadenylation and nuclear splicing surveillance, two important mechanisms of RNA-based regulation. Using the multifunctional SR proteins as an example, we want to understand how the information in the mRNA guides mRNPs assembly, how mRNP composition changes when the mRNA passes through distinct maturation steps and how the quality of nuclear gene expression is secured in eukaryotic cells.

Team

Michaela Müller-McNicoll (Principal Investigator)
 
Katharina Zarnack (Principal Investigator)
 
Oliver Daniel Schwich
Camila Freitas Stahl
Benjamin Arnold
Marius Wegener
Antonella Di Liddo
Mirko Brüggemann
Samarth Thonta Setty