B14 – Julia Weigand

Splicing regulation by conserved structural elements in the UTRs of human mRNAs

Alternative splicing is one of the most important mechanisms of posttranscriptional gene regulation in humans and greatly enhances the diversity of untranslated regions (UTRs) of mRNAs. These different UTRs dictate protein levels by altering mRNA stability and translation efficiency. The aim of this project is to investigate the regulation of alternative splicing of UTRs. Special focus lies on the importance of pre-mRNA structures, as little is known about the involvement of such structures in alternative splicing decisions. Further, if and how structure formation is regulated is under investigation. See also: Homepage Weigand Lab

Team

Julia Weigand (Principal Investigator)
 
Johannes Braun
 
Sandra Fischer