B07 – Robert Tampé

Control of mRNA translation and ribosome recycling by ABCE1

The twin-ATPase ABCE1 is one of the most conserved proteins in evolution and found in all Archaea and Eukarya, where it is essential for life. In the frame of the CRC 902, we have identified the fundamental function of ABCE1 in ribosome recycling, which is the final – or first – step of the cyclic process of mRNA translation. The recycling factor ABCE1 provides an important checkpoint in protein translation, ribosome biogenesis, and mRNA surveillance. Combining biochemical and biophysical approaches in archaeal and eukaryotic model systems, Sulfolobus solfataricus and Saccharomyces cerevisiae, we aim to obtain a detailed mechanistic understanding of ABCE1 in mRNA translational control and remodeling of RNA-protein complexes.

Team

Robert Tampé (Principal Investigator)
 
Elina Nürenberg
 
Milan Gerovac
 
Bianca Hetzert
 
Holger Pfitzner