Publication – Schuman

The central dogma decentralized: new perspectives on RNA function and local translation in neurons.

Holt CE, Schuman EM. Neuron. 2013 Oct 30. Abstract or full publication here.

The elaborate morphology of neurons together with the information processing that occurs in remote dendritic and axonal compartments makes the use of decentralized cell biological machines necessary. Recent years have witnessed a revolution in our understanding of signaling in neuronal compartments and the manifold functions of a variety of RNA molecules that regulate protein translation and other cellular functions. Here we discuss the view that mRNA localization and RNA-regulated and localized translation underlie many fundamental neuronal processes and highlight key issues for future experiments.