Posts Tagged ‘Schuman’

Das Proteom aktiver Nervenzellen

Pressemitteilung

Das Proteom aktiver Nervenzellen

Max-Planck-Forscher entwickeln eine Technik, mit der sie neue Proteine in unterschiedlichen Zelltypen des Mäusegehirns messen können

Das Gehirn besteht aus einer Vielzahl unterschiedlicher Typen von Nerven- und Gliazellen. Da sie alle das gleiche Erbgut besitzen, muss diese Vielfalt auf den von ihnen gebildeten Proteinen beruhen. Für einen bestimmten Zelltyp konnte die Gesamtheit der Proteine – das sogenannte Proteom –bislang nicht bestimmt werden. Wissenschaftler der Max-Planck-Institute für Hirnforschung und für Biophysik in Frankfurt haben nun neue Methoden entwickelt, mit denen sie Änderungen im Proteom in einem bestimmten Zelltyp erkennen können. Sie veröffentlichen diese Ergebnisse und deren Bedeutung in der Zeitschrift Nature Biotechnology.

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2nd RMU-RNA Salon

On Wednesday, June 28, the Goethe-Universität Frankfurt, in association with the SFB 902 and the RNA Society, will host the 2nd RNA Salon of the Rhein-Main Universitäten Associacion. Keynote Speaker will be Erin Schuman of the MPI for Brain Research, who recently received her second ERC advanced grant.

Presenting Groups:

AG Legewie (IMB Mainz) – Modelling of Biological Networks

AG Preußer (BCI, JLU Gießen) – CircRNAs & Exosomes

AG Randau (MPI Marburg) – Small RNomics & RIP-seq

AG Roignant (IMB Mainz) – RNA Modifications

AG Schmidt (IBC1, GU Frankfurt) – Ribo-seq

AG Zarnack (BMLS, GU Frankfurt) – Computational RNA Biology

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Erin Schuman receives her second ERC Advanced Grant for NeuroRibo project

With this prestigious grant of 2.5 million Euro, Erin Schuman, Director at the Frankfurt-based Max Planck Institute for Brain Research (MPI-BR) since 2009, will study extended functions of the ribosome, the protein-making machine, in neurons. Ribosomes are complex, yet conserved, multiprotein machines and Schuman’s team will study how they are specialized to synthesize proteins in the distal aspects of neuronal dendrites.

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Guest Speaker – Anna Ephrussi

Dear friends of RNA,

We are pleased to announce the first speaker of the Minerva Lecture series:

Anne Ephrussi
European Molecular Biology Laboratory (EMBL)
Heidelberg

Assembly of mRNPs for transport within and between cells of the Drosophila germline

Wednesday, March 22, 2017

4:00 pm

Hosts:
Erin Schuman
MPI for Brain Research
Synaptic Plasticity

Michaela Müller-McNicoll
Cluster of Excellence Macromolecular Complexes (CEF)
Goethe Universität Frankfurt

Lecture hall, MPI for Brain Research
Max-von-Laue-Str. 4, 60438 Frankfurt

Publication – Heckel, Schuman

Activity-dependent spatially localized miRNA maturation in neuronal dendrites

Sambandan S, Akbalik G, Kochen L, Rinne J, Kahlstatt J, Glock C, Tushev G, Alvarez-Castelao B, Heckel A, Schuman EM
Science. 2017 Feb 10. Abstract   Read more …

Publication – Schuman

Unconventional secretory processing diversifies neuronal ion channel properties

Hanus C, Geptin H, Tushev G, Garg S, Alvarez-Castelao B, Sambandan S, Kochen L, Hafner AS, Langer JD, Schuman EM

eLife 2016;5:e20609 Abstract Read more …

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Nature Methods publication – Schuman

Direct visualization of newly synthesized target proteins in situ.

Tom Dieck S, Kochen L, Hanus C, Heumüller M, Bartnik I, Nassim-Assir B, Merk K, Mosler T, Garg S, Bunse S, Tirrell DA, Schuman EM. Nat Methods. 2015 May. Abstract Read more …

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Nature Neuroscience publication – Schuman

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.

You X, Vlatkovic I, Babic A, Will T, Epstein I, Tushev G, Akbalik G, Wang M, Glock C, Quedenau C, Wang X, Hou J, Liu H, Sun W, Sambandan S, Chen T, Schuman EM, Chen W. Nat Neurosci. 2015 Feb 25. Press release Read more …

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Publication – Schuman

The central dogma decentralized: new perspectives on RNA function and local translation in neurons.

Holt CE, Schuman EM. Neuron. 2013 Oct 30. Abstract Read more …

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Publication – Schuman

Proteostasis in complex dendrites.

Hanus C, Schuman EM. Nat Rev Neurosci. 2013 Sep. Abstract Read more …

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Publication – Schuman

Axonal translation of β-catenin regulates synaptic vesicle assembly.

Taylor AM, Wu J, Tai HC, Schuman EM. J Neurosci, 2013 Mar 27. Abstract Read more …

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Publication – Schuman

A mutant methionyl-tRNA synthetase from bacteria enables site-selective N-terminal labeling of proteins expressed in mammalian cells.

Ngo JT, Schuman EM, Tirrell DA. Proc Natl Acad Sci U S A, 2013 March 11. Abstract Read more …

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The Remarkable Neuron – Erin Schuman

Prof. Erin Schuman (B1), Director of the Max Planck Institute for Brain Research presented her work at the TEDx Caltech conference.

On January 18, 2013, Caltech hosted TEDxCaltech: The Brain, a forward-looking celebration of humankind’s quest to understand the brain, by exploring the past, present and future of neuroscience. Erin Schuman presented her work on protein synthesis at the synapses. Her presentation was titled “The Remarkable Neuron” was recently put online and can be found on YouTube (http://www.youtube.com/watch?v=yr6kh_QOk0s) or on the website of TEDxCaltech. Read more …

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Publication – Schuman

Dopaminergic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT).

Hodas JJ, Nehring A, Höche N, Sweredoski MJ, Pielot R, Hess S, Tirrell DA, Dieterich DC, Schuman EM. Proteomics, 2012 Aug 12. Abstract Read more …

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Publication – Schuman

State-selective metabolic labeling of cellular proteins.

Ngo JT, Babin BM, Champion JA, Schuman EM, Tirrell DA. ACS Chem Biol, 2012 Aug 17. Abstract Read more …

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Publication – Schuman

The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging.

Cajigas IJ, Tushev G, Will TJ, Tom Dieck S, Fuerst N, Schuman EM. Neuron, 2012 May 10. Abstract Read more …

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Publication – Schuman

Non-canonical amino acid labeling in vivo to visualize and affinity purify newly synthesized proteins in larval zebrafish.

Hinz FI, Dieterich DC, Tirrell DA, Schuman EM. ACS Chem Neurosci, 2012 Jan 18. Abstract Read more …

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